Sphingomyelin Phosphodiesterase
"Sphingomyelin Phosphodiesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
| Descriptor ID |
D013108
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| MeSH Number(s) |
D08.811.277.352.640.750
|
| Concept/Terms |
Sphingomyelin Phosphodiesterase- Sphingomyelin Phosphodiesterase
- Sphingomyelin Cleaving Enzyme
- Sphingomyelinase C
- Sphingomyelinase
- Sphingomyelin Cholinephosphohydrolase
|
Below are MeSH descriptors whose meaning is more general than "Sphingomyelin Phosphodiesterase".
Below are MeSH descriptors whose meaning is more specific than "Sphingomyelin Phosphodiesterase".
This graph shows the total number of publications written about "Sphingomyelin Phosphodiesterase" by people in this website by year, and whether "Sphingomyelin Phosphodiesterase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sphingomyelin Phosphodiesterase" by people in Profiles.
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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957.
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Loss of SMPD4 Causes a Developmental Disorder Characterized by Microcephaly and Congenital Arthrogryposis. Am J Hum Genet. 2019 10 03; 105(4):689-705.
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Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution. Cell Physiol Biochem. 2018; 45(5):1999-2008.
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Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells. J Neurochem. 2016 12; 139(5):872-885.
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The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity. Biochim Biophys Acta. 2016 Feb; 1861(2):78-90.
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Spreading depression transiently disrupts myelin via interferon-gamma signaling. Exp Neurol. 2015 Feb; 264:43-54.
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Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One. 2013; 8(8):e69025.
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Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice. FEBS Lett. 2012 Nov 16; 586(22):4002-9.
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Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage. Stroke. 2012 Aug; 43(8):2066-70.
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Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem. 2012 Apr 20; 287(17):13620-32.