"Pirenzepine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
| Descriptor ID |
D010890
|
| MeSH Number(s) |
D03.633.100.079.080.070.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pirenzepine".
Below are MeSH descriptors whose meaning is more specific than "Pirenzepine".
This graph shows the total number of publications written about "Pirenzepine" by people in this website by year, and whether "Pirenzepine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pirenzepine" by people in Profiles.
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Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs. J Biol Chem. 2016 Jun 17; 291(25):13132-46.
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Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. J Cardiovasc Pharmacol. 2003 May; 41(5):671-7.
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Successful treatment of nondelusional body dysmorphic disorder with olanzapine: a case report. J Clin Psychiatry. 2001 Apr; 62(4):297-8.
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Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1091-100.
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Managing the behavioral and psychological signs and symptoms of dementia. Int Clin Psychopharmacol. 1997 Sep; 12 Suppl 4:S25-8.
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Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase. FEBS Lett. 1994 Jun 20; 347(1):27-30.
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Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis. Am Rev Respir Dis. 1993 Feb; 147(2):327-31.
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The effect of pirenzepine on meal-stimulated gastrointestinal hormones. Scand J Gastroenterol Suppl. 1980; 66:57-61.