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Arjun Raman

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Email
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    Collapse Overview 
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    Biological systems are thought to be exceedingly 'complex'--comprised of many parts and sets of unintuitive interactions between parts conferring system function. My lab is interested in elucidating principles of structure, function, and adaptability relationships with the ultimate goals of (i) characterizing 'personalized' variation in biological systems with high-fidelity, (ii) creating tools to genetically engineer variation in a rational way, and (iii) engineering natural-like, adaptive systems de novo. We use a blend of theory, computation, and experiment applied to a range of model systems spanning neural networks to electronic health record data to complex ecosystems inhabiting humans in addressing these concepts.

    Collapse Biography 
    Collapse education and training
    University of Chicago, ChicagoB.A.06/2008Physics
    University of Chicago, ChicagoB.S.06/2008Chemistry (Honors)
    University of Texas at Southwestern, DallasM.D.06/2017Medicine
    University of Texas at Southwestern, DallasPh.D.06/2017Molecular Biophysics
    Washington University in St. Louis, St. Louis06/2020Clinical Pathology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Raman AS. Combatting superbugs using the evolutionary record of microbial warfare. Cell Host Microbe. 2024 Jul 10; 32(7):1037-1039. PMID: 38991497.
      Citations:    Fields:    Translation:HumansCells
    2. Doran BA, Chen RY, Giba H, Behera V, Barat B, Sundararajan A, Lin H, Sidebottom A, Pamer EG, Raman AS. An evolution-based framework for describing human gut bacteria. bioRxiv. 2023 Dec 05. PMID: 38105970; PMCID: PMC10723311.
      Citations:    
    3. Zaydman MA, Little AS, Haro F, Aksianiuk V, Buchser WJ, DiAntonio A, Gordon JI, Milbrandt J, Raman AS. Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes. Elife. 2022 08 17; 11. PMID: 35976223; PMCID: PMC9427106.
      Citations: 2     Fields:    Translation:Cells
    4. Delannoy-Bruno O, Desai C, Raman AS, Chen RY, Hibberd MC, Cheng J, Han N, Castillo JJ, Couture G, Lebrilla CB, Barve RA, Leyn SA, Rodionov DA, Osterman AL, Hayashi DK, Meynier A, Vinoy S, Kirbach K, Wilmot T, Heath AC, Klein S, Barratt MJ, Gordon JI, Lombard V, Henrissat B. Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans. Nature. 2021 07; 595(7865):91-95. PMID: 34163075; PMCID: PMC8324079.
      Citations: 48     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    5. Chen RY, Mostafa I, Hibberd MC, Das S, Mahfuz M, Naila NN, Islam MM, Huq S, Alam MA, Zaman MU, Raman AS, Webber D, Zhou C, Sundaresan V, Ahsan K, Meier MF, Barratt MJ, Ahmed T, Gordon JI. A Microbiota-Directed Food Intervention for Undernourished Children. N Engl J Med. 2021 04 22; 384(16):1517-1528. PMID: 33826814; PMCID: PMC7993600.
      Citations: 86     Fields:    Translation:Humans
    6. López García de Lomana A, Kusebauch U, Raman AV, Pan M, Turkarslan S, Lorenzetti APR, Moritz RL, Baliga NS. Selective Translation of Low Abundance and Upregulated Transcripts in Halobacterium salinarum. mSystems. 2020 Jul 28; 5(4). PMID: 32723790; PMCID: PMC7394353.
      Citations: 5     Fields:    
    7. Bode L, Raman AS, Murch SH, Rollins NC, Gordon JI. Understanding the mother-breastmilk-infant "triad". Science. 2020 03 06; 367(6482):1070-1072. PMID: 32139527.
      Citations: 45     Fields:    Translation:Humans
    8. Feng L, Raman AS, Hibberd MC, Cheng J, Griffin NW, Peng Y, Leyn SA, Rodionov DA, Osterman AL, Gordon JI. Identifying determinants of bacterial fitness in a model of human gut microbial succession. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2622-2633. PMID: 31969452; PMCID: PMC7007522.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    9. Raman AS, Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Subramanian S, Kang G, Bessong PO, Kosek MN, Petri WA, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Huq S, Mostafa I, Islam M, Mahfuz M, Haque R, Ahmed T, Barratt MJ, Gordon JI, Lima AAM. A sparse covarying unit that describes healthy and impaired human gut microbiota development. Science. 2019 07 12; 365(6449). PMID: 31296739; PMCID: PMC6683326.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    10. Raman AS, White KI, Ranganathan R. Origins of Allostery and Evolvability in Proteins: A Case Study. Cell. 2016 Jul 14; 166(2):468-480. PMID: 27321669.
      Citations: 63     Fields:    Translation:AnimalsCells
    11. McLaughlin RN, Poelwijk FJ, Raman A, Gosal WS, Ranganathan R. The spatial architecture of protein function and adaptation. Nature. 2012 Nov 01; 491(7422):138-42. PMID: 23041932; PMCID: PMC3991786.
      Citations: 235     Fields:    Translation:Cells
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