"Aphidicolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
| Descriptor ID |
D016590
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| MeSH Number(s) |
D02.455.849.291.075
|
| Concept/Terms |
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer- Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
|
Below are MeSH descriptors whose meaning is more general than "Aphidicolin".
Below are MeSH descriptors whose meaning is more specific than "Aphidicolin".
This graph shows the total number of publications written about "Aphidicolin" by people in this website by year, and whether "Aphidicolin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aphidicolin" by people in Profiles.
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Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks. PLoS One. 2013; 8(4):e60043.
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Impaired replication dynamics at the FRA3B common fragile site. Hum Mol Genet. 2010 Jan 01; 19(1):99-110.
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KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1174-80.
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Requirements for activation of CD8+ murine T cells. I. Development of cytolytic activity. Immunol Res. 1994; 13(4):215-33.
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The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells. Exp Cell Res. 1992 Nov; 203(1):100-6.