"Neurofilament Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
| Descriptor ID |
D016900
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| MeSH Number(s) |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Neurofilament Proteins".
Below are MeSH descriptors whose meaning is more specific than "Neurofilament Proteins".
This graph shows the total number of publications written about "Neurofilament Proteins" by people in this website by year, and whether "Neurofilament Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2025 | 1 | 2 | 3 |
| 2026 | 1 | 3 | 4 |
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Below are the most recent publications written about "Neurofilament Proteins" by people in Profiles.
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Relationships of CSF biomarkers to cortical atrophy in early-onset Alzheimer's disease. Alzheimers Dement. 2026 Jul; 22(7):e71479.
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Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus. JAMA Neurol. 2026 Jun 01; 83(6):563-572.
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Predictive models for ataxia progression and conversion in spinocerebellar ataxia type 1 and 3. Brain. 2026 Apr 07; 149(4):1268-1277.
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Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America. Nat Aging. 2026 Feb; 6(2):430-444.
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Plasma markers of neurological injury are elevated in preeclampsia. Pregnancy Hypertens. 2025 Dec; 42:101265.
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Language impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome. Alzheimers Dement. 2025 07; 21(7):e70485.
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A preliminary study on plasma markers across cognitive stages and links to a history of mild traumatic brain injury. J Alzheimers Dis. 2025 05; 105(1):49-55.
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CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2018 01 23; 90(4):e273-e281.
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Cancer Chemotherapy in Early Life Significantly Alters the Maturation of Pain Processing. Neuroscience. 2018 09 01; 387:214-229.
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The effect of functionalizing lipid nanocapsules with NFL-TBS.40-63 peptide on their uptake by glioblastoma cells. Biomaterials. 2013 Apr; 34(13):3381-9.