Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance.

Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance. Nucleic Acids Res. 2021 06 04; 49(10):5588-5604.

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subject areas

BRCA2 Protein
Breast Neoplasms
DNA Repair
Female
HEK293 Cells
HeLa Cells
Homologous Recombination
Humans
Mutation, Missense
Ovarian Neoplasms
Proteasome Endopeptidase Complex
Protein Binding

authors with profiles

Ben Hall