"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
| Descriptor ID |
D011485
|
| MeSH Number(s) |
G02.111.679 G03.808
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protein Binding".
Below are MeSH descriptors whose meaning is more specific than "Protein Binding".
This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 6 | 6 |
| 1996 | 0 | 14 | 14 |
| 1997 | 0 | 9 | 9 |
| 1998 | 0 | 16 | 16 |
| 1999 | 0 | 19 | 19 |
| 2000 | 0 | 33 | 33 |
| 2001 | 0 | 30 | 30 |
| 2002 | 0 | 51 | 51 |
| 2003 | 0 | 33 | 33 |
| 2004 | 0 | 48 | 48 |
| 2005 | 1 | 52 | 53 |
| 2006 | 0 | 36 | 36 |
| 2007 | 0 | 45 | 45 |
| 2008 | 1 | 39 | 40 |
| 2009 | 0 | 61 | 61 |
| 2010 | 0 | 61 | 61 |
| 2011 | 1 | 62 | 63 |
| 2012 | 0 | 56 | 56 |
| 2013 | 0 | 61 | 61 |
| 2014 | 0 | 52 | 52 |
| 2015 | 1 | 56 | 57 |
| 2016 | 0 | 51 | 51 |
| 2017 | 0 | 50 | 50 |
| 2018 | 0 | 41 | 41 |
| 2019 | 0 | 28 | 28 |
| 2020 | 0 | 32 | 32 |
| 2021 | 0 | 28 | 28 |
| 2022 | 0 | 12 | 12 |
| 2023 | 0 | 9 | 9 |
| 2024 | 4 | 9 | 13 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Binding" by people in Profiles.
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A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro. Sci Adv. 2025 Jan 10; 11(2):eadq2616.
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Binding mode-guided development of high-performance antibodies targeting site-specific posttranslational modifications. Proc Natl Acad Sci U S A. 2025 Jan 07; 122(1):e2411720121.
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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function. Nat Commun. 2024 Dec 04; 15(1):10545.
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Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Structure. 2024 Nov 07; 32(11):1936-1951.e5.
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A Method for Treating Significant Conformational Changes in Alchemical Free Energy Simulations of Protein-Ligand Binding. J Chem Theory Comput. 2024 Oct 08; 20(19):8609-8623.
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The prolyl isomerase FKBP11 is a secretory translocon accessory factor. Mol Biol Cell. 2024 Nov 01; 35(11):ar135.
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RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 Sep 05; 84(17):3192-3208.e11.
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Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol. 2024 06 17; 7(1):733.
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Epistasis facilitates functional evolution in an ancient transcription factor. Elife. 2024 May 20; 12.
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Parkinson's disease-associated mutations in a-synuclein alters its lipid-bound state. Biophys J. 2024 06 18; 123(12):1610-1619.