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The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
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The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med. 2012 Nov; 18(11):1643-50.
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PubMed
subject areas
Acetylation
Animals
Cardiomegaly
Chromatin
DNA-Binding Proteins
Heart Failure
Histone Demethylases
Insulin-Like Growth Factor I
JNK Mitogen-Activated Protein Kinases
Mice
Mice, Transgenic
Oncogene Protein v-akt
Promoter Regions, Genetic
Signal Transduction
Sirtuins
authors with profiles
Valluvan Jeevanandam
John Cunningham
Gene H. Kim
Mahesh P. Gupta