Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012 Mar; 122(3):948-62.

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subject areas

Animals
Bone Marrow Transplantation
Calcineurin
Chromosomes, Human, Pair 21
Disease Models, Animal
Down Syndrome
GATA1 Transcription Factor
Humans
Leukemia, Megakaryoblastic, Acute
Mice
Models, Genetic
Mutation
Protein-Tyrosine Kinases
Risk
Thrombocytosis

authors with profiles

Sandeep Gurbuxani