"Thrombospondin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
| Descriptor ID |
D019700
|
| MeSH Number(s) |
D12.776.395.550.895.800 D12.776.543.550.895.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombospondin 1".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondin 1".
This graph shows the total number of publications written about "Thrombospondin 1" by people in this website by year, and whether "Thrombospondin 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Thrombospondin 1" by people in Profiles.
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An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis. Neoplasia. 2020 08; 22(8):294-310.
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Targeting Vessel Formation in Pulmonary Arterial Hypertension: Is the Endostatin-Id1-Thrombospondin 1 Pathway a New Hope? Am J Respir Cell Mol Biol. 2020 04; 62(4):411-412.
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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346.
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Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res. 2013 Dec 06; 113(12):1331-44.
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Initiation of aspirin therapy modulates angiogenic protein levels in women with breast cancer receiving tamoxifen therapy. Clin Transl Sci. 2013 Oct; 6(5):386-90.
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The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression. Oncogene. 2013 Sep 12; 32(37):4377-86.
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Vatalanib in malignant mesothelioma: a phase II trial by the Cancer and Leukemia Group B (CALGB 30107). Lung Cancer. 2012 Jun; 76(3):393-6.
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Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension. 2011 Nov; 58(5):902-11.
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Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines. BMC Cancer. 2010 Jun 14; 10:286.
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Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation. Lab Invest. 2010 Jul; 90(7):1078-90.