"Conotoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
| Descriptor ID |
D020916
|
| MeSH Number(s) |
D20.888.590.162 D23.946.580.590.162 D23.946.833.590.162
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Conotoxins".
Below are MeSH descriptors whose meaning is more specific than "Conotoxins".
This graph shows the total number of publications written about "Conotoxins" by people in this website by year, and whether "Conotoxins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Conotoxins" by people in Profiles.
-
Closed-Locked and Apo-Resting State Structures of the Human a7 Nicotinic Receptor: A Computational Study. J Chem Inf Model. 2018 11 26; 58(11):2278-2293.
-
Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin. J Gen Physiol. 2002 Jan; 119(1):45-54.
-
mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains. J Gen Physiol. 2000 Nov; 116(5):679-90.
-
Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. Biochemistry. 1998 Mar 31; 37(13):4407-19.
-
A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. Biophys J. 1995 Nov; 69(5):1657-65.