Project Goals: The overall goal of this study is to target proteins that promote efficient DNA damage repair in neuroblastoma to abrogate treatment resistance and improve the outcome of children with high-risk.
Specific Aims: 1) To functionally characterize how MELK, EZH2, and MYCN mediate competent HR DSB repair. 2) To investigate the activity of PARP inhibitors in neuroblastoma cells with HR deficiency due to
MELK, EZH2, or MYCN inhibition and treatment resistance in neuroblastoma cells: