Tripartite Motif-Containing Protein 28
"Tripartite Motif-Containing Protein 28" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
| Descriptor ID |
D000076183
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| MeSH Number(s) |
D08.811.464.938.750.782 D12.776.260.703.675 D12.776.930.780.911 D12.776.934.875
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tripartite Motif-Containing Protein 28".
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tripartite Motif-Containing Protein 28" by people in Profiles.
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KAP1 controls endogenous retroviruses in embryonic stem cells. Nature. 2010 Jan 14; 463(7278):237-40.