Histamine H1 Antagonists, Non-Sedating
"Histamine H1 Antagonists, Non-Sedating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
| Descriptor ID |
D039563
|
| MeSH Number(s) |
D27.505.519.625.375.425.400.500 D27.505.696.577.375.425.400.500
|
| Concept/Terms |
Histamine H1 Antagonists, Non-Sedating- Histamine H1 Antagonists, Non-Sedating
- Histamine H1 Antagonists, Non Sedating
- Second Generation H1 Antagonists
- H1 Antihistamines, Non-Sedating
- H1 Antihistamines, Non Sedating
- Non-Sedating H1 Antihistamines
- Second Generation Antihistamines
- Antihistamines, Second Generation
|
Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists, Non-Sedating".
Below are MeSH descriptors whose meaning is more specific than "Histamine H1 Antagonists, Non-Sedating".
This graph shows the total number of publications written about "Histamine H1 Antagonists, Non-Sedating" by people in this website by year, and whether "Histamine H1 Antagonists, Non-Sedating" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histamine H1 Antagonists, Non-Sedating" by people in Profiles.
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Molecular Origin of the Distinct Tabletability of Loratadine and Desloratadine: Role of the Bonding Area - Bonding Strength Interplay. Pharm Res. 2020 Jun 28; 37(7):133.
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Advertisements impact the physiological efficacy of a branded drug. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):12931-5.
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Suicide and prescription rates of intranasal corticosteroids and nonsedating antihistamines for allergic rhinitis: an ecological study. J Clin Psychiatry. 2011 Oct; 72(10):1423-8.
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Elucidating the mechanism underlying the ocular symptoms associated with allergic rhinitis. Allergy Asthma Proc. 2008 Jan-Feb; 29(1):24-8.
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Acute bacterial rhinosinusitis causes hyperresponsiveness to histamine challenge in mice. Arch Otolaryngol Head Neck Surg. 2005 Oct; 131(10):905-10.
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Desloratadine partially inhibits the augmented bacterial responses in the sinuses of allergic and infected mice. Clin Exp Allergy. 2004 Oct; 34(10):1649-54.
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Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2004 Jan; 92(1):73-9.
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Fluticasone nasal spray and the combination of loratadine and montelukast in seasonal allergic rhinitis. Arch Otolaryngol Head Neck Surg. 2003 May; 129(5):557-62.