"Histamine H1 Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
| Descriptor ID |
D006634
|
| MeSH Number(s) |
D27.505.519.625.375.425.400 D27.505.696.577.375.425.400
|
| Concept/Terms |
Histamine H1 Antagonists- Histamine H1 Antagonists
- H1 Antagonists, Histamine
- Antagonists, Histamine H1 Receptor
- Antihistaminics, H1
- H1 Antihistaminics
- Receptor Blockaders, H1
- H1 Receptor Blockaders
- Histamine H1 Blockers
- Histamine H1 Receptor Antagonists
- Histamine H1 Receptor Blockaders
- Antagonists, Histamine H1
- Blockaders, Histamine H1 Receptor
Antihistamines, Classical- Antihistamines, Classical
- Classical Antihistamines
- Antihistaminics, Classical
- Classical Antihistaminics
- First Generation H1 Antagonists
- Antihistamines, Sedating
- Sedating Antihistamines
|
Below are MeSH descriptors whose meaning is more general than "Histamine H1 Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Histamine H1 Antagonists".
This graph shows the total number of publications written about "Histamine H1 Antagonists" by people in this website by year, and whether "Histamine H1 Antagonists" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 1 | 0 | 1 |
| 2001 | 2 | 0 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 2 | 1 | 3 |
| 2005 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histamine H1 Antagonists" by people in Profiles.
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Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2. Mol Cancer Ther. 2020 10; 19(10):2023-2033.
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Expedited Development of Diphenhydramine Orally Disintegrating Tablet through Integrated Crystal and Particle Engineering. Mol Pharm. 2017 10 02; 14(10):3399-3408.
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Olopatadine hydrochloride ophthalmic solution for the treatment of allergic conjunctivitis. Expert Opin Pharmacother. 2017 Aug; 18(11):1137-1143.
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Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose. Clin Toxicol (Phila). 2010 Nov; 48(9):945-8.
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H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res. 2009 Nov; 60(5):429-37.
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Treatment modalities, health care resource utilization, and costs in patients diagnosed with interstitial cystitis. Am J Obstet Gynecol. 2008 Jul; 199(1):71.e1-10.
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Pharmacologic treatment of persons with dizziness. Neurol Clin. 2005 Aug; 23(3):831-53, vii.
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Premedication and infusion reactions with infliximab: results from a pediatric inflammatory bowel disease consortium. Inflamm Bowel Dis. 2005 May; 11(5):442-6.
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Requirements for medications commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI), Allergic Rhinitis and its Impact on Asthma (ARIA). Allergy. 2003 Mar; 58(3):192-7.
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Rhabdomyolysis associated with unintentional antihistamine overdose in a child. Pediatr Emerg Care. 2003 Feb; 19(1):25-6.