"TATA-Box Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.
| Descriptor ID |
D035181
|
| MeSH Number(s) |
D12.776.260.775.374 D12.776.260.775.875.750.500 D12.776.930.930.374 D12.776.930.930.875.750.500
|
| Concept/Terms |
TATA-Box Binding Protein- TATA-Box Binding Protein
- TATA Box Binding Protein
- Transcription Factor TBP
- TATA-Box-Binding Protein
- RNA Polymerase II TATA-Binding Protein
- RNA Polymerase II TATA Binding Protein
- TATA-Binding Protein
- TATA Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "TATA-Box Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "TATA-Box Binding Protein".
This graph shows the total number of publications written about "TATA-Box Binding Protein" by people in this website by year, and whether "TATA-Box Binding Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 2 | 3 |
| 2006 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "TATA-Box Binding Protein" by people in Profiles.
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Recombinant expression and purification of human TATA binding protein using a chimeric fusion. Protein Expr Purif. 2012 Sep; 85(1):142-7.
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A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene. Mol Cell Biol. 2007 Feb; 27(3):878-87.
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Polyglutamine protein aggregates are dynamic. Nat Cell Biol. 2002 Oct; 4(10):826-31.
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POU/TBP cooperativity: a mechanism for enhancer action from a distance. Mol Cell. 2002 Aug; 10(2):397-407.
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The TBP-inhibitory domain of TAF145 limits the effects of nonclassical transcriptional activators. Curr Biol. 2002 Jun 04; 12(11):934-7.
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The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. Int Immunol. 2000 Jul; 12(7):1085-93.