"Progeria" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
| Descriptor ID |
D011371
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| MeSH Number(s) |
C16.320.565.753 C18.452.648.753
|
| Concept/Terms |
Progeria- Progeria
- Hutchinson-Gilford Syndrome
- Hutchinson Gilford Syndrome
- Hutchinson Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndromes
- Progeria Syndrome, Hutchinson-Gilford
- Progeria Syndromes, Hutchinson-Gilford
|
Below are MeSH descriptors whose meaning is more general than "Progeria".
Below are MeSH descriptors whose meaning is more specific than "Progeria".
This graph shows the total number of publications written about "Progeria" by people in this website by year, and whether "Progeria" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Progeria" by people in Profiles.
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Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies. Nucleus. 2020 12; 11(1):299-314.
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Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Dev Cell. 2020 03 23; 52(6):699-713.e11.
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Welcome to the splice age: antisense oligonucleotide-mediated exon skipping gains wider applicability. J Clin Invest. 2016 Apr 01; 126(4):1236-8.
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TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends. Nat Commun. 2014 Nov 17; 5:5467.
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The retinol acid receptor B gene is hypermethylated in patients with familial partial lipodystrophy. J Mol Endocrinol. 2007 Jun; 38(6):663-71.
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Gastrointestinal complications of spinal cord injury. Spine (Phila Pa 1976). 1981 Nov-Dec; 6(6):538-44.
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X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders. Cancer Res. 1980 Mar; 40(3):920-5.