"PPAR alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
| Descriptor ID |
D047493
|
| MeSH Number(s) |
D12.776.826.239.500
|
| Concept/Terms |
PPAR alpha- PPAR alpha
- Peroxisome Proliferator-Activated Receptor alpha
- Peroxisome Proliferator Activated Receptor alpha
- PPARalpha
|
Below are MeSH descriptors whose meaning is more general than "PPAR alpha".
Below are MeSH descriptors whose meaning is more specific than "PPAR alpha".
This graph shows the total number of publications written about "PPAR alpha" by people in this website by year, and whether "PPAR alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "PPAR alpha" by people in Profiles.
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Adiponectin Stimulates Apolipoprotein A-1 Gene Expression in HepG2 Cells via AMPK, PPARa, and LXRs Signaling Mechanisms. Biochemistry (Mosc). 2022 Nov; 87(11):1252-1259.
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N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathy. Eur J Pain. 2021 07; 25(6):1367-1380.
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Targeting Peroxisome Proliferator-Activated Receptor-a (PPAR- a) to reduce paclitaxel-induced peripheral neuropathy. Brain Behav Immun. 2021 03; 93:172-185.
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Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. Cell Rep. 2018 11 13; 25(7):1816-1828.e4.
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Tumor necrosis factor a stimulates endogenous apolipoprotein A-I expression and secretion by human monocytes and macrophages: role of MAP-kinases, NF-?B, and nuclear receptors PPARa and LXRs. Mol Cell Biochem. 2018 Nov; 448(1-2):211-223.
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Homeostatic PPARa Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine. J Immunol. 2016 06 01; 196(11):4739-49.
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PPAR? Represses Apolipoprotein A-I Gene but Impedes TNFa-Mediated ApoA-I Downregulation in HepG2 Cells. J Cell Biochem. 2016 09; 117(9):2010-22.
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Peroxisome proliferator-activated receptor a positively regulates complement C3 expression but inhibits tumor necrosis factor a-mediated activation of C3 gene in mammalian hepatic-derived cells. J Biol Chem. 2013 Jan 18; 288(3):1726-38.
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Effect of TNFalpha on activities of different promoters of human apolipoprotein A-I gene. Biochem Biophys Res Commun. 2010 Jul 23; 398(2):224-30.
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Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells. Biochemistry. 2009 Dec 22; 48(50):11950-60.