"Tunicamycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.
| Descriptor ID |
D014415
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| MeSH Number(s) |
D03.383.742.680.725 D13.570.685.725
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tunicamycin".
Below are MeSH descriptors whose meaning is more specific than "Tunicamycin".
This graph shows the total number of publications written about "Tunicamycin" by people in this website by year, and whether "Tunicamycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tunicamycin" by people in Profiles.
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High-throughput allele-specific expression across 250 environmental conditions. Genome Res. 2016 12; 26(12):1627-1638.
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tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Mol Biol Cell. 2015 Jan 15; 26(2):270-82.
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Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices. J Neurol Sci. 2012 Jun 15; 317(1-2):66-73.
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Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol. 2011 Dec; 25(12):2065-75.
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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell. 2009 Nov 13; 36(3):487-99.
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Glycosylation and annexin II cell surface translocation mediate airway epithelial wound repair. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L354-63.
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Polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein. J Biol Chem. 2005 Sep 30; 280(39):33497-505.
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A polypeptide binding conformation of calreticulin is induced by heat shock, calcium depletion, or by deletion of the C-terminal acidic region. Mol Cell. 2004 Sep 24; 15(6):913-23.
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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003 Mar; 11(3):619-33.
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Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring. J Biol Chem. 2002 May 03; 277(18):16241-8.