"Synaptotagmin I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vesicular transport protein expressed predominately in NEURONS. Synaptotagmin helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.
| Descriptor ID |
D050863
|
| MeSH Number(s) |
D12.776.157.125.825.249 D12.776.543.990.850.249
|
| Concept/Terms |
Synaptotagmin I- Synaptotagmin I
- p65 Protein (Synaptotagmin I)
- Synaptic Vesicle Protein p65
- Synaptotagmin 1
|
Below are MeSH descriptors whose meaning is more general than "Synaptotagmin I".
Below are MeSH descriptors whose meaning is more specific than "Synaptotagmin I".
This graph shows the total number of publications written about "Synaptotagmin I" by people in this website by year, and whether "Synaptotagmin I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synaptotagmin I" by people in Profiles.
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The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature. 2017 08 24; 548(7668):420-425.
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Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex. Elife. 2016 10 12; 5.
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N-terminal domain of complexin independently activates calcium-triggered fusion. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4698-707.
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Interaction of anesthetics with neurotransmitter release machinery proteins. J Neurophysiol. 2013 Feb; 109(3):758-67.
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Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous. J Mol Biol. 2011 Jan 21; 405(3):696-706.
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Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G203-11.
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Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. J Mol Biol. 2009 Jul 31; 390(5):913-23.
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Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G202-10.
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Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1549-58.
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A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol. 2007 Mar 30; 367(3):848-63.