"Thymidylate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
| Descriptor ID |
D013940
|
| MeSH Number(s) |
D08.811.913.555.500.862
|
| Concept/Terms |
Thymidylate Synthase- Thymidylate Synthase
- Synthase, Thymidylate
- Thymidylate Synthetase
- Synthetase, Thymidylate
|
Below are MeSH descriptors whose meaning is more general than "Thymidylate Synthase".
Below are MeSH descriptors whose meaning is more specific than "Thymidylate Synthase".
This graph shows the total number of publications written about "Thymidylate Synthase" by people in this website by year, and whether "Thymidylate Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2001 | 2 | 1 | 3 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thymidylate Synthase" by people in Profiles.
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Molecular profiling in gastric cancer: examining potential targets for chemotherapy. J Surg Oncol. 2014 Sep; 110(3):302-6.
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Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed in patients with malignant pleural mesothelioma. J Thorac Oncol. 2013 Apr; 8(4):469-77.
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Etodolac improves 5-FU sensitivity of head and neck cancer cells through inhibition of thymidylate synthase. Anticancer Res. 2011 Sep; 31(9):2893-8.
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Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005 Jun 15; 105(12):4752-8.
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The emerging role of pemetrexed for the treatment of malignant mesothelioma. Oncology (Williston Park). 2004 Jul; 18(8 Suppl 5):49-53.
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Pharmacogenomics: road to anticancer therapeutics nirvana? Oncogene. 2003 Sep 29; 22(42):6621-8.
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Pemetrexed in pancreatic cancer. Semin Oncol. 2002 Dec; 29(6 Suppl 18):49-53.
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Update on pharmacogenetics in cancer chemotherapy. Eur J Cancer. 2002 Mar; 38(5):639-44.
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Molecular markers and prediction of response to chemoradiation in rectal cancer. Oncol Rep. 2001 May-Jun; 8(3):497-500.
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Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. Cancer. 2001 Apr 01; 91(7):1256-63.