"Complement C3a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
| Descriptor ID |
D015926
|
| MeSH Number(s) |
D12.776.124.486.274.024.250 D12.776.124.486.274.250.250
|
| Concept/Terms |
Complement C3a- Complement C3a
- C3a, Complement
- Complement 3a
- Complement Component 3a
- Component 3a, Complement
- C3a Complement
- Complement, C3a
|
Below are MeSH descriptors whose meaning is more general than "Complement C3a".
Below are MeSH descriptors whose meaning is more specific than "Complement C3a".
This graph shows the total number of publications written about "Complement C3a" by people in this website by year, and whether "Complement C3a" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C3a" by people in Profiles.
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Muscle, myeloid cells, and complement: a complex interaction. Cell Mol Immunol. 2018 11; 15(11):992-993.
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Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients. Sci Rep. 2016 Feb 03; 6:20341.
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Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. Kidney Int. 2011 Sep; 80(5):524-34.
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C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol. 2007 Feb 01; 178(3):1819-28.
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Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol. 2005 Aug 01; 175(3):1947-55.
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Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children. Ann Thorac Surg. 2000 May; 69(5):1490-5.
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Transgenic swine lungs expressing human CD59 are protected from injury in a pig-to-human model of xenotransplantation. J Thorac Cardiovasc Surg. 2000 Apr; 119(4 Pt 1):690-9.
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Hemodynamic effects of methylprednisolone in patients undergoing cardiac operation and early extubation. Ann Thorac Surg. 1999 Apr; 67(4):1006-11.
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Alkylation of cellulosic membranes results in reduced complement activation. J Biomater Sci Polym Ed. 1996; 7(8):707-14.
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Complement activation and lung permeability during cardiopulmonary bypass. Ann Thorac Surg. 1990 Oct; 50(4):597-601.