"Polyadenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
| Descriptor ID |
D026723
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| MeSH Number(s) |
G02.111.760.225.710 G03.839.225.710 G05.308.700.225.710
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polyadenylation".
Below are MeSH descriptors whose meaning is more specific than "Polyadenylation".
This graph shows the total number of publications written about "Polyadenylation" by people in this website by year, and whether "Polyadenylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 2 | 1 | 3 |
| 2023 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polyadenylation" by people in Profiles.
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Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts. Cell Rep. 2025 Feb 25; 44(2):115283.
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Infernape uncovers cell type-specific and spatially resolved alternative polyadenylation in the brain. Genome Res. 2023 10; 33(10):1774-1787.
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Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation. Genome Biol. 2021 10 14; 22(1):291.
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Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees. Elife. 2021 02 17; 10.
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Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nat Commun. 2021 01 19; 12(1):448.
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Alternative polyadenylation mediates genetic regulation of gene expression. Elife. 2020 06 25; 9.
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A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PLoS One. 2013; 8(10):e76290.
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Characterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patients. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18066-71.