"Angiopoietin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first to be discovered member of the angiopoietin family. It may play a role in increasing the sprouting and branching of BLOOD VESSELS. Angiopoietin-1 specifically binds to and stimulates the TIE-2 RECEPTOR. Several isoforms of angiopoietin-1 occur due to ALTERNATIVE SPLICING of its mRNA.
| Descriptor ID |
D042683
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| MeSH Number(s) |
D12.644.276.100.100.100 D12.776.467.100.100.100 D23.529.100.100.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Angiopoietin-1".
Below are MeSH descriptors whose meaning is more specific than "Angiopoietin-1".
This graph shows the total number of publications written about "Angiopoietin-1" by people in this website by year, and whether "Angiopoietin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Angiopoietin-1" by people in Profiles.
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Angiopoietin 1 Attenuates Dysregulated Angiogenesis in the Gastrocnemius of DMD Mice. Int J Mol Sci. 2024 Nov 04; 25(21).
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Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1. Crit Care. 2023 06 26; 27(1):250.
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Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):1298-1303.
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ANG1 treatment reduces muscle pathology and prevents a decline in perfusion in DMD mice. PLoS One. 2017; 12(3):e0174315.
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A phase II trial of trebananib (AMG 386; IND#111071), a selective angiopoietin 1/2 neutralizing peptibody, in patients with persistent/recurrent carcinoma of the endometrium: An NRG/Gynecologic Oncology Group trial. Gynecol Oncol. 2015 Sep; 138(3):513-8.
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Alliance A091103 a phase II study of the angiopoietin 1 and 2 peptibody trebananib for the treatment of angiosarcoma. Cancer Chemother Pharmacol. 2015 Mar; 75(3):629-38.
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A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014 Oct; 124(10):4320-4.
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Localization of angiopoietin-1 and Tie2 immunoreactivity in rodent ependyma and adjacent blood vessels suggests functional relationships. J Histochem Cytochem. 2010 Jan; 58(1):53-60.
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Colorectal resection is associated with persistent proangiogenic plasma protein changes: postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion. Ann Surg. 2009 Jun; 249(6):973-7.
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Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol. 2009 Jan; 34(1):79-87.