"Cytosine Deaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can also act on 5-methylcytosine to form THYMIDINE.
| Descriptor ID |
D043525
|
| MeSH Number(s) |
D08.811.277.151.486.625
|
| Concept/Terms |
Cytosine Deaminase- Cytosine Deaminase
- Deaminase, Cytosine
- Cytosine Aminohydrolase
- Aminohydrolase, Cytosine
|
Below are MeSH descriptors whose meaning is more general than "Cytosine Deaminase".
Below are MeSH descriptors whose meaning is more specific than "Cytosine Deaminase".
This graph shows the total number of publications written about "Cytosine Deaminase" by people in this website by year, and whether "Cytosine Deaminase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 3 | 0 | 3 |
| 2006 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cytosine Deaminase" by people in Profiles.
-
Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors. Cancer Gene Ther. 2007 Jan; 14(1):45-56.
-
Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol Cell Biol. 2005 Dec; 25(24):10815-21.
-
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med. 2005 Nov 21; 202(10):1443-54.
-
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J Exp Med. 2005 May 02; 201(9):1467-78.
-
Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization. Cancer Gene Ther. 2005 Mar; 12(3):284-94.
-
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12997-3002.
-
Gene therapy enhances the antiproliferative effect of radiation in intimal hyperplasia. J Surg Res. 2000 Apr; 89(2):155-62.
-
Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res. 1997 Oct 01; 57(19):4205-9.
-
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther. 1996 Apr 10; 7(6):713-20.