"Nodal Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.
| Descriptor ID |
D055457
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| MeSH Number(s) |
D12.644.276.954.550.650 D12.776.467.942.550.650 D23.529.942.550.650
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nodal Protein".
Below are MeSH descriptors whose meaning is more specific than "Nodal Protein".
This graph shows the total number of publications written about "Nodal Protein" by people in this website by year, and whether "Nodal Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nodal Protein" by people in Profiles.
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BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. Hum Mol Genet. 2010 Aug 01; 19(15):3030-42.
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Nodal signalling is involved in left-right asymmetry in snails. Nature. 2009 Feb 19; 457(7232):1007-11.
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BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. Development. 2008 Aug; 135(14):2425-34.
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Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo. Development. 2004 Jul; 131(14):3381-90.
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The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation. Development. 2003 Nov; 130(22):5503-17.