Heparin-binding EGF-like Growth Factor
"Heparin-binding EGF-like Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
| Descriptor ID |
D066257
|
| MeSH Number(s) |
D12.644.276.382.625 D12.776.467.382.625 D23.529.382.625
|
| Concept/Terms |
Short Form HB-EGF- Short Form HB-EGF
- HB-EGF, Short Form
- Short Form HB EGF
- SF HB-EGF
- SF HB EGF
Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein- Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
- Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
- Receptor, Diphtheria Toxin
- HB-EGF Precursor
- HB EGF Precursor
- Diphtheria Toxin Receptor
- Toxin Receptor, Diphtheria
- Diphtheria Toxin Receptors
- Receptors, Diphtheria Toxin
- Toxin Receptors, Diphtheria
|
Below are MeSH descriptors whose meaning is more general than "Heparin-binding EGF-like Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Heparin-binding EGF-like Growth Factor".
This graph shows the total number of publications written about "Heparin-binding EGF-like Growth Factor" by people in this website by year, and whether "Heparin-binding EGF-like Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Heparin-binding EGF-like Growth Factor" by people in Profiles.
-
Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema. JCI Insight. 2016 09 22; 1(15):e84095.
-
Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis. Circ Res. 2016 05 13; 118(10):1480-97.
-
LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling. PLoS One. 2011; 6(11):e27720.
-
HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res. 2004 Aug 01; 64(15):5283-90.
-
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity. 2002 Aug; 17(2):211-20.
-
Histopathological and immunohistochemical studies on arteritis induced by fenoldopam, a vasodilator, in rats. Exp Toxicol Pathol. 2001 Apr; 53(1):25-30.