"Chromosome Breakage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.
| Descriptor ID |
D019457
|
| MeSH Number(s) |
C23.550.210.170 G05.200.210.170 G05.365.590.175.175
|
| Concept/Terms |
Chromosome Breakage- Chromosome Breakage
- Breakage, Chromosome
- Breakages, Chromosome
- Chromosome Breakages
- Chromosomal Breakage
- Breakage, Chromosomal
- Breakages, Chromosomal
- Chromosomal Breakages
Chromosome Breaks- Chromosome Breaks
- Break, Chromosome
- Breaks, Chromosome
- Chromosome Break
- Chromosomal Breaks
- Break, Chromosomal
- Breaks, Chromosomal
- Chromosomal Break
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Breakage".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Breakage".
This graph shows the total number of publications written about "Chromosome Breakage" by people in this website by year, and whether "Chromosome Breakage" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 1 | 3 |
| 2008 | 0 | 3 | 3 |
| 2015 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromosome Breakage" by people in Profiles.
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Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620938941.
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Histone modifications predispose genome regions to breakage and translocation. Genes Dev. 2015 Jul 01; 29(13):1393-402.
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Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks. PLoS One. 2013; 8(4):e60043.
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Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution. BMC Evol Biol. 2009 Apr 24; 9:84.
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A novel mechanistic spectrum underlies glaucoma-associated chromosome 6p25 copy number variation. Hum Mol Genet. 2008 Nov 15; 17(22):3446-58.
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Consistent chromosome abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27, and 21q2. Am J Med Genet A. 2008 Jul 01; 146A(13):1637-54.
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Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster. Nat Genet. 2008 Jun; 40(6):719-21.
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Recurrent 16p11.2 microdeletions in autism. Hum Mol Genet. 2008 Feb 15; 17(4):628-38.
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''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 cases. J Mol Diagn. 2007 Sep; 9(4):530-7.
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Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum. Am J Hum Genet. 2007 Aug; 81(2):292-303.