"Focal Adhesion Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.
| Descriptor ID |
D051418
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.049.750 D23.050.301.500.600.350 D23.050.705.552.600.350
|
| Concept/Terms |
Focal Adhesion Kinase 2- Focal Adhesion Kinase 2
- RAFTK Protein
- Cell Adhesion Kinase Beta
- Proline-Rich Tyrosine Kinase 2
- Proline Rich Tyrosine Kinase 2
- Related Adhesion Focal Tyrosine Kinase
- CADTK Protein
- Focal Adhesion Kinase Autokinase
- FAK Autokinase
- Calcium-Dependent Protein Tyrosine Kinase
- Calcium Dependent Protein Tyrosine Kinase
- PYK2 Protein Tyrosine Kinase
- Protein Tyrosine Kinase PYK2
|
Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Kinase 2".
This graph shows the total number of publications written about "Focal Adhesion Kinase 2" by people in this website by year, and whether "Focal Adhesion Kinase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Focal Adhesion Kinase 2" by people in Profiles.
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Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. Cancer Biol Ther. 2018 04 03; 19(4):316-327.
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Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury. Respir Res. 2012 Jan 18; 13:4.
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Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2010 Apr; 42(4):491-7.
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Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):263-9.
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PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol. 2008 Jan 14; 180(1):187-203.
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Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space. Shock. 2006 May; 25(5):440-5.
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NADPH oxidase activation in fibronectin adherent human neutrophils: A potential role for beta1 integrin ligation. Surgery. 2003 Aug; 134(2):378-83.
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Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14978-83.
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The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. J Biol Chem. 1996 Dec 06; 271(49):31222-6.