"Bryostatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
| Descriptor ID |
D054713
|
| MeSH Number(s) |
D02.540.576.500.937
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Bryostatins".
Below are MeSH descriptors whose meaning is more specific than "Bryostatins".
This graph shows the total number of publications written about "Bryostatins" by people in this website by year, and whether "Bryostatins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Bryostatins" by people in Profiles.
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A randomized phase II trial of interleukin-2 in combination with four different doses of bryostatin-1 in patients with renal cell carcinoma. Invest New Drugs. 2006 Mar; 24(2):141-9.
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Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins. Am J Physiol Cell Physiol. 2003 Aug; 285(2):C300-9.
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A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer. Lung Cancer. 2003 Feb; 39(2):191-6.
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Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes. Am J Physiol Gastrointest Liver Physiol. 2003 Apr; 284(4):G703-12.
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Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):204-13.
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Effect of protein kinase C on endoplasmic reticulum cholesterol. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):488-93.
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Phase II studies of bryostatin-1 in patients with advanced sarcoma and advanced head and neck cancer. Invest New Drugs. 2001; 19(3):249-54.