Christopher Rhodes to Signal Transduction
This is a "connection" page, showing publications Christopher Rhodes has written about Signal Transduction.
Connection Strength
1.362
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Direct autocrine action of insulin on ß-cells: does it make physiological sense? Diabetes. 2013 Jul; 62(7):2157-63.
Score: 0.202
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells. Mol Cell Endocrinol. 2003 Jun 30; 204(1-2):85-99.
Score: 0.101
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Molecular insights into insulin action and secretion. Eur J Clin Invest. 2002 Jun; 32 Suppl 3:3-13.
Score: 0.094
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes. 2002 Apr; 51(4):966-76.
Score: 0.093
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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication. J Mol Endocrinol. 2000 Jun; 24(3):303-11.
Score: 0.082
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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2019 03; 7(3):227-238.
Score: 0.074
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):356-66.
Score: 0.058
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH. Hum Mol Genet. 2012 Jun 01; 21(11):2548-58.
Score: 0.046
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):32-8.
Score: 0.038
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Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol. 2006 Apr; 26(7):2675-87.
Score: 0.031
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Type 2 diabetes-a matter of beta-cell life and death? Science. 2005 Jan 21; 307(5708):380-4.
Score: 0.028
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Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. Circulation. 2024 Oct 15; 150(16):1268-1287.
Score: 0.027
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab. 2004 Aug; 287(2):E192-8.
Score: 0.027
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A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 2004 Apr; 53(4):1007-19.
Score: 0.027
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol. 2003 Nov 14; 209(1-2):17-31.
Score: 0.026
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem. 2002 Dec 20; 277(51):49676-84.
Score: 0.024
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? Trends Mol Med. 2002 Aug; 8(8):375-84.
Score: 0.024
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002 Aug; 51(8):2496-504.
Score: 0.024
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Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature. 2001 Oct 25; 413(6858):794-5.
Score: 0.022
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem. 2001 Jun 15; 276(24):21110-20.
Score: 0.022
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Nat Commun. 2020 03 04; 11(1):1185.
Score: 0.020
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production. Nat Commun. 2019 02 12; 10(1):714.
Score: 0.019
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem. 1998 Jul 10; 273(28):17771-9.
Score: 0.018
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension. Nat Commun. 2018 04 12; 9(1):1416.
Score: 0.018
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The dynamic plasticity of insulin production in ß-cells. Mol Metab. 2017 09; 6(9):958-973.
Score: 0.016
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Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016 Jan; 90(1):1-37.
Score: 0.015
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a1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders. Circ Cardiovasc Genet. 2014 Dec; 7(6):920-9.
Score: 0.014
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014 Jun; 37(6):1751-8.
Score: 0.013
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014 Jun; 99(6):1983-92.
Score: 0.013
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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 2011 Nov; 60(11):2843-52.
Score: 0.011
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation. PLoS One. 2011 Apr 26; 6(4):e18146.
Score: 0.011
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology. 2011 Feb; 152(2):436-46.
Score: 0.011
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Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1. J Endocrinol. 2010 Aug; 206(2):171-81.
Score: 0.010
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol. 2010 Mar; 298(3):R720-8.
Score: 0.010
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology. 2009 Oct; 150(10):4502-11.
Score: 0.010
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology. 2009 Feb; 150(2):580-91.
Score: 0.009
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Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription. Diabetes. 2006 Oct; 55(10):2723-9.
Score: 0.008
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem. 2006 Aug 25; 281(34):24293-303.
Score: 0.008
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem. 2006 Jun 09; 281(23):15884-92.
Score: 0.008
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Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006 Mar 10; 160(1):1-40.
Score: 0.008
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005 Dec; 2(6):411-20.
Score: 0.007
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Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest. 2005 Mar; 115(3):703-10.
Score: 0.007
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Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun. 2003 Aug; 71(8):4414-20.
Score: 0.006
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes. 2001 Oct; 50(10):2237-43.
Score: 0.006
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. Endocrinology. 2001 Jan; 142(1):229-40.
Score: 0.005
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Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
Score: 0.005
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J. 1999 Dec 15; 344 Pt 3:649-58.
Score: 0.005
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998 Jul; 47(7):1074-85.
Score: 0.004