"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
| Descriptor ID |
D018628
|
| MeSH Number(s) |
G05.380.350
|
| Concept/Terms |
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
|
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in this website by year, and whether "Gene Dosage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 4 | 4 |
| 1998 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 3 | 4 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 2 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 3 | 4 | 7 |
| 2007 | 3 | 4 | 7 |
| 2008 | 10 | 7 | 17 |
| 2009 | 6 | 9 | 15 |
| 2010 | 2 | 4 | 6 |
| 2011 | 3 | 7 | 10 |
| 2012 | 1 | 5 | 6 |
| 2013 | 1 | 11 | 12 |
| 2014 | 0 | 6 | 6 |
| 2015 | 0 | 6 | 6 |
| 2016 | 2 | 2 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 1 | 3 |
| 2019 | 0 | 6 | 6 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 1 | 1 |
| 2026 | 1 | 2 | 3 |
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click here.
Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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The Genomic Landscape of MYC-, MYCL-, and MYCN-Amplified Solid Tumors. Clin Cancer Res. 2026 Sep 15; 32(18):4124-4135.
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Buffering of gene dosage response curves for human complex traits. Cell Genom. 2026 Jul 08; 6(7):101221.
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Spinal muscular atrophy among US Hutterites: Phenotype variability in the setting of conserved ancestral haplotype and 4 SMN2 copies. Genet Med. 2026 04; 28(4):102535.
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Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA. Nat Commun. 2021 02 08; 12(1):874.
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Sporadic oncocytic tumors with features intermediate between oncocytoma and chromophobe renal cell carcinoma: comprehensive clinicopathological and genomic profiling. Hum Pathol. 2020 10; 104:18-29.
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Genomic characterization of diffuse large B-cell lymphoma transformation of nodular lymphocyte-predominant Hodgkin lymphoma. Leukemia. 2020 08; 34(8):2238-2242.
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The evolutionary history of 2,658 cancers. Nature. 2020 02; 578(7793):122-128.
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Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 2020 02 05; 11(1):735.
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Genetic regulatory variation in populations informs transcriptome analysis in rare disease. Science. 2019 10 18; 366(6463):351-356.
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Female adnexal tumors of probable Wolffian origin: morphological, immunohistochemical, and molecular analysis of 15 cases. Mod Pathol. 2020 04; 33(4):734-747.