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Kaloyan Tsanov

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
ORCID ORCID Icon0000-0001-9007-4844 Additional info
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    Collapse Overview 
    Collapse overview
    The Tsanov laboratory investigates metastatic disease – the major cause of cancer-related deaths. The overall goal of our research is to elucidate mechanisms that sustain metastatic tumors and to identify related vulnerabilities that can be therapeutically targeted. We focus on pancreatic and gastric adenocarcinomas, and integrate innovative mouse models, functional genetics tools and multiomic approaches to dissect the interplay of genetic, epigenetic and microenvironmental factors in metastatic tumors. Our vision is that understanding natural barriers to metastasis and tumor–microenvironment crosstalk at different metastatic sites will reveal a set of governing principles that can be leveraged for novel therapies that are specifically tailored to metastatic tumors.

    Collapse Biography 
    Collapse education and training
    Memorial Sloan Kettering Cancer Center, New York, NYPostdoctoral Fellowship2024Cancer Biology & Genetics
    Harvard University, Cambridge, MAPhD2017Biological & Biomedical Sciences
    Harvard University, Cambridge, MAAB2009Molecular & Cellular Biology
    Collapse awards and honors
    2024Forbeck Scholar Award, William Guy Forbeck Research Foundation
    2024MSK Postdoctoral Research Award, Memorial Sloan Kettering Cancer Center
    2022NIH K99/R00 Pathway to Independence Award
    2022Benjamin F. Trump Award for Scientific Research Excellence, Aspen Cancer Conference
    2021 - 2022Shulamit Katzman Endowed Postdoctoral Research Fellowship, Memorial Sloan Kettering Cancer Center
    2018 - 2021Jane Coffin Childs Postdoctoral Fellowship
    2013 - 2015Howard Hughes Medical Institute International Student Research Fellowship
    2012Harvard University Certificate of Distinction in Teaching, Harvard University
    2010 - 2012Herchel Smith Graduate Fellowship, Harvard University
    2009Lawrence J. Henderson Prize, Harvard University

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhao X, Liu B, William WN, Tsanov KM, Ho YJ, Barriga FM, Lim RJ, Trifas M, Du Y, Lowe SW, Dubinett SM, Davoli T, Lippman SM. Interferon-e loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction. J Thorac Oncol. 2024 Dec 24. PMID: 39725169.
      Citations:    Fields:    
    2. Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov KM, Mattagajasingh O, Di Gioacchino A, Marhon SA, Chacon-Barahona J, Li H, Jiang H, Hozeifi S, Rosas-Bringas O, Xu KH, Song Y, Lang ER, Rojas AS, Nieman LT, Patel BK, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, Zenklusen D, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD. Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms. Immunity. 2024 12 10; 57(12):2879-2894.e11. PMID: 39577413.
      Citations:    Fields:    
    3. Tsanov KM, Barriga FM, Ho YJ, Alonso-Curbelo D, Livshits G, Koche RP, Baslan T, Simon J, Tian S, Wuest AN, Luan W, Wilkinson JE, Masilionis I, Dimitrova N, Iacobuzio-Donahue CA, Chaligné R, Pe'er D, Massagué J, Lowe SW. Metastatic site influences driver gene function in pancreatic cancer. bioRxiv. 2024 Mar 18. PMID: 38562717; PMCID: PMC10983983.
      Citations:    
    4. Leibold J, Tsanov KM, Amor C, Ho YJ, Sánchez-Rivera FJ, Feucht J, Baslan T, Chen HA, Tian S, Simon J, Wuest A, Wilkinson JE, Lowe SW. Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nat Cancer. 2024 Feb; 5(2):315-329. PMID: 38177458; PMCID: PMC10899107.
      Citations: 4     Fields:    Translation:HumansAnimals
    5. Schwörer S, Cimino FV, Ros M, Tsanov KM, Ng C, Lowe SW, Carmona-Fontaine C, Thompson CB. Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines. Cancer Res. 2023 05 15; 83(10):1596-1610. PMID: 36912618; PMCID: PMC10658995.
      Citations: 23     Fields:    Translation:HumansCells
    6. Barriga FM, Tsanov KM, Ho YJ, Sohail N, Zhang A, Baslan T, Wuest AN, Del Priore I, Meškauskaite B, Livshits G, Alonso-Curbelo D, Simon J, Chaves-Perez A, Bar-Sagi D, Iacobuzio-Donahue CA, Notta F, Chaligne R, Sharma R, Pe'er D, Lowe SW. MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis. Nat Cancer. 2022 11; 3(11):1367-1385. PMID: 36344707; PMCID: PMC9701143.
      Citations: 35     Fields:    Translation:AnimalsCells
    7. Baslan T, Morris JP, Zhao Z, Reyes J, Ho YJ, Tsanov KM, Bermeo J, Tian S, Zhang S, Askan G, Yavas A, Lecomte N, Erakky A, Varghese AM, Zhang A, Kendall J, Ghiban E, Chorbadjiev L, Wu J, Dimitrova N, Chadalavada K, Nanjangud GJ, Bandlamudi C, Gong Y, Donoghue MTA, Socci ND, Krasnitz A, Notta F, Leach SD, Iacobuzio-Donahue CA, Lowe SW. Ordered and deterministic cancer genome evolution after p53 loss. Nature. 2022 08; 608(7924):795-802. PMID: 35978189; PMCID: PMC9402436.
      Citations: 81     Fields:    Translation:Animals
    8. Sánchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE. Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022 06; 40(6):862-873. PMID: 35165384; PMCID: PMC9232935.
      Citations: 40     Fields:    Translation:Animals
    9. Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ. LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. J Clin Invest. 2021 11 15; 131(22). PMID: 34779407; PMCID: PMC8592552.
      Citations: 13     Fields:    
    10. Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ. Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 2021 07 20; 36(3):109408. PMID: 34289374; PMCID: PMC8371695.
      Citations: 4     Fields:    Translation:HumansCells
    11. Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe'er D, Lowe SW. A gene-environment-induced epigenetic program initiates tumorigenesis. Nature. 2021 02; 590(7847):642-648. PMID: 33536616; PMCID: PMC8482641.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    12. Leibold J, Ruscetti M, Cao Z, Ho YJ, Baslan T, Zou M, Abida W, Feucht J, Han T, Barriga FM, Tsanov KM, Zamechek L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado NR, Sánchez-Rivera FJ, Watson PA, de Stanchina E, Wilkinson JE, Dow LE, Abate-Shen C, Sawyers CL, Lowe SW. Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. Cancer Discov. 2020 07; 10(7):1038-1057. PMID: 32376773; PMCID: PMC7334089.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    13. Cesana M, Guo MH, Cacchiarelli D, Wahlster L, Barragan J, Doulatov S, Vo LT, Salvatori B, Trapnell C, Clement K, Cahan P, Tsanov KM, Sousa PM, Tazon-Vega B, Bolondi A, Giorgi FM, Califano A, Rinn JL, Meissner A, Hirschhorn JN, Daley GQ. A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. Cell Stem Cell. 2018 04 05; 22(4):575-588.e7. PMID: 29625070; PMCID: PMC5957284.
      Citations: 31     Fields:    Translation:HumansCells
    14. Tsanov KM, Daley GQ. Signaling through RNA-binding proteins as a cell fate regulatory mechanism. Cell Cycle. 2017 04 18; 16(8):723-724. PMID: 28272977; PMCID: PMC5405717.
      Citations: 1     Fields:    Translation:Cells
    15. Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. PMID: 27992407; PMCID: PMC5182091.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    16. Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016 07 14; 535(7611):246-51. PMID: 27383785; PMCID: PMC4947006.
      Citations: 100     Fields:    Translation:HumansAnimals
    17. Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013 Nov 07; 155(4):778-92. PMID: 24209617; PMCID: PMC3917449.
      Citations: 200     Fields:    Translation:HumansAnimals
    18. Tsanov KM, Nishi Y, Peterson KA, Liu J, Baetscher M, McMahon AP. An embryonic stem cell-based system for rapid analysis of transcriptional enhancers. Genesis. 2012 May; 50(5):443-50. PMID: 22083581; PMCID: PMC3334447.
      Citations: 3     Fields:    Translation:HumansCells
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