The University of Chicago Header Logo

Elijah Darnell

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
ORCID ORCID Icon0000-0001-5535-084X Additional info
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Dr. Darnell is an expert in the treatment of B- and T-cell lymphomas and chronic lymphocytic leukemia (CLL). He has a special interest in clinical investigation of novel agents for the treatment of lymphoma including CAR T-cell therapy, bispecific antibodies, targeted therapies, and other immune therapies. He leads research in the development of novel CAR T-cell therapies and is an investigator for efforts to use combinatorial therapy with CAR T-cells to overcome resistant lymphomas. He is additionally interested in the immunologic consequences of CLL and leads an effort to develop a functional characterization of immunity to guide infection prevention in patients with CLL.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Darnell EP, Gallagher KME, Kanska J, Scarfò I, Balderrama-Gutierrez G, Berger TR, Budka J, Bozym DJ, Huang T, Shen R, Leick MB, Maus MV. Ibrutinib exposure correlates with improved efficacy of CAR T cells in patients with mantle cell lymphoma. Blood Adv. 2026 Feb 24; 10(4):1023-1034. PMID: 41733967.
      Citations:    
    2. Park S, Ho CE, Darnell EP, Wolff AN, Takei H, Birocchi F, Bouffard AA, Salas-Benito D, Escobar G, Leick MB, Mucci A, Berger TR, Maus MV. Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer. Nat Commun. 2025 Dec 10; 16(1):11246. PMID: 41372740; PMCID: PMC12717153.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Knudsen NH, Escobar G, Korell F, Kienka T, Nobrega C, Anderson S, Cheng AY, Zschummel M, Armstrong A, Bouffard A, Kann MC, Goncalves S, Pope HW, Pezeshki M, Rojas A, Suermondt JSMT, Phillips M, Berger TR, Park S, Salas-Benito D, Darnell EP, Birocchi F, Leick MB, Larson RC, Doench JG, Sen D, Yates KB, Manguso RT, Maus MV. In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma. Nature. 2025 Oct; 646(8086):953-962. PMID: 40993381; PMCID: PMC12806180.
      Citations:    
    4. Supper VM, Donner H, Birocchi F, Bratt A, Escobar G, Kann MC, Park S, Martin G, Korell F, Takei H, Armstrong A, Parker A, Salas-Benito D, Darnell EP, Bailey SR, Kienka T, Philips M, Bouffard A, Goncalves S, Choi BD, Haradhvala NJ, Maus MV, Leick MB. Secretion of a VEGF-Blocking scFv Enhances CAR T-cell Potency. Cancer Immunol Res. 2025 Aug 01; 13(8):1132-1144. PMID: 40455064; PMCID: PMC12777652.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Haydu JE, Lei MM, Redd RA, Barnes JA, Darnell EP, Hochberg EP, Johnson PC, Takvorian RW, Weitzman JI, Woods EC, Hurvitz TL, Lafranchi CD, Livingstone P, Lynch JM, Patterson EN, Malespini JE, McGree BM, Santilli AO, Thorp KA, Sherburne MM, Wardrop LB, Lou UY, Sorial MN, Cho C, Ford J, Nemac R, Soumerai JD, Abramson JS. A prospective study of prophylactic dexamethasone with glofitamab in relapsed/refractory large B-cell lymphoma. Blood Neoplasia. 2025 Nov; 2(4):100147. PMID: 41424939; PMCID: PMC12711648.
      Citations:    
    6. Bailey SR, Takei HN, Escobar G, Kann MC, Bouffard AA, Kienka T, Supper VM, Armstrong A, Salas-Benito D, Phillips MK, Birocchi F, Vatsa S, Silva H, Scarfò I, Wehrli M, Grauwet K, Darnell EP, Graham CE, Leick MB, Korell F, Berger TR, Maus MV. IFN-?-resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models. Sci Transl Med. 2025 Jun 04; 17(801):eadp8166. PMID: 40465687; PMCID: PMC12687918.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Soumerai JD, Yousif Z, Gift T, Desai R, Huynh L, Ye M, Banatwala A, Clear L, Pinaire M, Belsky G, Hsieh YG, Herrick C, Darnell EP, Duh MS, Sanchirico M, Murphy SN. IgG testing, immunoglobulin replacement therapy, and infection outcomes in patients with CLL or NHL: real-world evidence. Blood Adv. 2024 08 27; 8(16):4239-4249. PMID: 38904477; PMCID: PMC11372570.
      Citations: 12     Fields:    Translation:Humans
    8. Darnell EP, Maus MV. Tumor burden in ZUMA-7: less is more. Blood. 2024 06 13; 143(24):2441-2442. PMID: 38869918.
      Citations:    Fields:    Translation:Humans
    9. Darnell EP, Maus MV. Context matters: Tumor microenvironments impact cellular therapy success. Cell Rep Med. 2024 Apr 16; 5(4):101491. PMID: 38631291; PMCID: PMC11031417.
      Citations:    Fields:    
    10. Darnell EP, Frigault MJ. Two years later: CD19 CAR-T going the distance. Blood. 2024 02 01; 143(5):379-380. PMID: 38300610.
      Citations: 1     Fields:    Translation:Humans
    11. Camacho DF, Velez TE, Hollinger MK, Wang E, Howard CL, Darnell EP, Kennedy DE, Krishack PA, Hrusch CL, Clark MR, Moon JJ, Sperling AI. IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses. JCI Insight. 2022 11 08; 7(21). PMID: 36194494; PMCID: PMC9675458.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Darnell EP, Jacobson CA. German CARs keeping pace. Blood. 2022 07 28; 140(4):296-298. PMID: 35900785.
      Citations:    Fields:    Translation:Humans
    13. Darnell EP, Wang TJ, Lumish MA, Hernandez-Barco YG, Weniger M, Casey BW, Qadan M, Lillemoe KD, Ferrone CR, Fernandez-Del Castillo C, Krishnan K. Preoperative cholangitis is an independent risk factor for mortality in patients after pancreatoduodenectomy for pancreatic cancer. Am J Surg. 2021 01; 221(1):134-140. PMID: 32847686.
      Citations: 13     Fields:    Translation:Humans
    14. Darnell EP, Wroblewski KE, Pagel KL, Kern DW, McClintock MK, Pinto JM. IL-1Rahigh-IL-4low-IL-13low: A Novel Plasma Cytokine Signature Associated with Olfactory Dysfunction in Older US Adults. Chem Senses. 2020 05 29; 45(5):407-414. PMID: 32369568; PMCID: PMC7320218.
      Citations:    Fields:    Translation:Humans
    15. Darnell EP, Mooradian MJ, Baruch EN, Yilmaz M, Reynolds KL. Immune-Related Adverse Events (irAEs): Diagnosis, Management, and Clinical Pearls. Curr Oncol Rep. 2020 03 21; 22(4):39. PMID: 32200442.
      Citations: 227     Fields:    Translation:Humans
    Darnell's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (82)
    Explore
    _
    Co-Authors (4)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _