A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.

A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14.

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subject areas

Animals
Anti-Inflammatory Agents
Brain
CHO Cells
Chronic Disease
Cricetinae
Cricetulus
HEK293 Cells
Humans
Inflammation
Male
Molecular Targeted Therapy
Neuralgia
Phenylurea Compounds
Protein Isoforms
Quinolines
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate
Sodium Channel Blockers
Voltage-Gated Sodium Channels