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Rebay, Ilaria
One or more keywords matched the following properties of Rebay, Ilaria
PropertyValue
keywords Signal Transduction Pathways
overview The long-term goal of research in the Rebay Lab is to understand how signaling networks, cytoskeletal dynamics and tissue geometry work together to direct specific developmental decisions and programs. We use the developing Drosophila eye and heart as tractable model systems in which to explore how cell fates are specified and organized into functional tissues and organs. Our experimental approach is multidisciplinary, and incorporates molecular genetics, genomics, quantitative imaging, biochemistry and mathematical modeling. Current projects are focused on transcriptional networks and cellular mechanisms that regulate and stabilize the transition from uncommitted progenitor to specified fate and on signaling mechanisms and tissue-level biomechanical properties that together drive terminal differentiation and morphogenesis.
One or more keywords matched the following items that are connected to Rebay, Ilaria
Item TypeName
Concept Nuclear Localization Signals
Concept Intercellular Signaling Peptides and Proteins
Concept MAP Kinase Signaling System
Concept Extracellular Signal-Regulated MAP Kinases
Concept Intracellular Signaling Peptides and Proteins
Concept Signal Transduction
Academic Article Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.
Academic Article Signal transduction downstream from Ras in Drosophila.
Academic Article split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells.
Academic Article Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway.
Academic Article CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE.
Academic Article Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.
Academic Article The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye.
Academic Article Splits ends is a tissue/promoter specific regulator of Wingless signaling.
Academic Article Keeping the receptor tyrosine kinase signaling pathway in check: lessons from Drosophila.
Academic Article Derepression by depolymerization; structural insights into the regulation of Yan by Mae.
Academic Article MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN.
Academic Article Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent.
Academic Article Signaling circuitries in development: insights from the retinal determination gene network.
Academic Article Intersection of signal transduction pathways and development.
Academic Article The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis.
Academic Article Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.
Academic Article Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.
Academic Article Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan.
Academic Article Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.
Academic Article Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.
Academic Article The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2.
Academic Article Ras signal transduction pathway in Drosophila eye development.
Academic Article The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription.
Academic Article The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.
Academic Article Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.
Academic Article Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.
Academic Article A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein.
Academic Article Signal integration during development: insights from the Drosophila eye.
Academic Article New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.
Academic Article Post-translational modifications influence transcription factor activity: a view from the ETS superfamily.
Academic Article Function of the ETS transcription factor Yan in border cell migration.
Academic Article Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila.
Academic Article The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors.
Academic Article Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise?
Academic Article A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.
Academic Article Multiple Functions of the Eya Phosphotyrosine Phosphatase.
Academic Article Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila.
Academic Article Drosophila Eye Nuclei Segmentation Based on Graph Cut and Convex Shape Prior.
Academic Article Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression.
Academic Article A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
Grant Specificity and dynamics of transcriptional repression in retinal development
Grant A systems-level study of signaling networks and differentiation
Grant Cell-Cell Signaling In Embryonic and Retinal Development
Search Criteria
  • Signaling
  • Pathways