Item Type | Name |
Concept
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Insulin
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Concept
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Insulin-Like Growth Factor II
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Concept
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Insulin Infusion Systems
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Concept
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Insulin-Like Growth Factor I
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Concept
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Insulin Antibodies
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Concept
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Receptor, Insulin
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Concept
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Insulin Resistance
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Concept
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Insulin-Like Growth Factor Binding Protein 3
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Concept
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Insulin-Secreting Cells
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Concept
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Insulin Receptor Substrate Proteins
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Academic Article
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Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats.
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Academic Article
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Defects in beta-cell function in functional ovarian hyperandrogenism.
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Academic Article
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Glucokinase mutations, insulin secretion, and diabetes mellitus.
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Academic Article
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
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Academic Article
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Ultradian oscillations of leptin secretion in humans.
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Academic Article
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Alterations in the kinetics of C-peptide and insulin secretion in hyperthyroidism.
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Academic Article
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Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance.
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Academic Article
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Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.
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Academic Article
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Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction.
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Academic Article
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Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome.
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Academic Article
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Report of the American Diabetes Association's Task Force on standardization of the insulin assay.
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Academic Article
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Analytical problems in detecting rapid insulin secretory pulses in normal humans.
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Academic Article
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Oscillatory insulin secretion after pancreas transplant.
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Academic Article
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Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans.
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Academic Article
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Effects of aging on glucose regulation during wakefulness and sleep.
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Academic Article
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Elevated plasma glucose 2 h postchallenge predicts defects in beta-cell function.
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Academic Article
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Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging.
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Academic Article
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Insulin acutely suppresses glucose production by both peripheral and hepatic effects in normal dogs.
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Academic Article
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Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals.
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Academic Article
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Basal and glucagon-stimulated plasma C-peptide concentrations in healthy dogs, dogs with diabetes mellitus, and dogs with hyperadrenocorticism.
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Academic Article
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
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Academic Article
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Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene.
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Academic Article
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Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome.
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Academic Article
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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
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Academic Article
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Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats.
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Academic Article
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Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.
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Academic Article
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Maturity onset diabetes of the young (MODY).
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Academic Article
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Diurnal variations in cardiovascular function and glucose regulation in normotensive humans.
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Academic Article
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Evidence that insulin can directly inhibit hepatic glucose production.
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Academic Article
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Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.
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Academic Article
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Alternative insulin delivery systems: how demanding should the patient be?
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Academic Article
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Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
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Academic Article
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Free fatty acids impair hepatic insulin extraction in vivo.
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Academic Article
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Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm.
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Academic Article
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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance.
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Academic Article
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Quantitative indexes of beta-cell function during graded up&down glucose infusion from C-peptide minimal models.
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Academic Article
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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.
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Academic Article
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Role of basal triglyceride and high density lipoprotein in determination of postprandial lipid and lipoprotein responses.
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Academic Article
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Effects of insulin mediated plasma glucose changes on brain function. Implications from experimental and derived data.
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Academic Article
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The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes.
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Academic Article
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GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.
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Academic Article
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Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.
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Academic Article
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Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance.
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Academic Article
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Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.
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Academic Article
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Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.
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Academic Article
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Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.
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Academic Article
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Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes.
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Academic Article
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Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in type 2 (non-insulin-dependent) diabetic patients.
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Academic Article
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Dynamics of insulin secretion in obesity and diabetes.
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Academic Article
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Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.
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Academic Article
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Insulin production: from gene to granule.
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Academic Article
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A practical approach to fasting hypoglycemia.
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Academic Article
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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
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Academic Article
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Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance.
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Academic Article
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Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes.
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Academic Article
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Temporal profiles and clinical significance of pulsatile insulin secretion.
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Academic Article
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Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.
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Academic Article
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Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
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Academic Article
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Hypoglycemic thresholds for cognitive dysfunction in IDDM.
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Academic Article
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Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.
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Academic Article
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Roles of insulin resistance and obesity in regulation of plasma insulin concentrations.
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Academic Article
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Insulin release in impaired glucose tolerance: oral minimal model predicts normal sensitivity to glucose but defective response times.
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Academic Article
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A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).
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Academic Article
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Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance.
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Academic Article
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Calpains play a role in insulin secretion and action.
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Academic Article
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Diabetes mellitus and genetically programmed defects in beta-cell function.
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Academic Article
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Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity.
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Academic Article
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Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component.
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Academic Article
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Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.
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Academic Article
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Increased islet apoptosis in Pdx1+/- mice.
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Academic Article
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A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
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Academic Article
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Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.
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Academic Article
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Persistence of oscillatory insulin secretion in denervated islet cell autografts.
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Academic Article
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Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome.
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Academic Article
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Entrainment of pulsatile insulin secretion by oscillatory glucose infusion.
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Academic Article
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Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities.
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Academic Article
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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
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Academic Article
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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
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Academic Article
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Nocturnal elevation of glucose levels during fasting in noninsulin-dependent diabetes.
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Academic Article
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Insulin sensitivity by oral glucose minimal models: validation against clamp.
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Academic Article
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Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals.
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Academic Article
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Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.
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Academic Article
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Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus.
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Academic Article
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Effect of temporal distribution of calories on diurnal patterns of glucose levels and insulin secretion in NIDDM.
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Academic Article
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The effect of a time delay on the characteristics of the canine glucoregulatory system.
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Academic Article
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Diabetic pancreatic beta cells ARNT all they should be.
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Academic Article
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Does tight glucose control enhance brain sensitivity to low glucose?
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Academic Article
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Postprandial triglyceride response in type 1 (insulin-dependent) diabetes mellitus is not altered by short-term deterioration in glycaemic control or level of postprandial insulin replacement.
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Academic Article
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Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography.
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Academic Article
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Retinol-binding protein 4, insulin resistance, and type 2 diabetes.
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Academic Article
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Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II.
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Academic Article
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Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites.
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Academic Article
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Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans.
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Academic Article
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Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
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Academic Article
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Computer model for mechanisms underlying ultradian oscillations of insulin and glucose.
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Academic Article
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Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells.
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Academic Article
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Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.
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Academic Article
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A significant role for histocompatibility in human islet transplantation.
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Academic Article
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Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals.
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Academic Article
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Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
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Academic Article
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Suppressed insulin signaling and increased apoptosis in CD38-null islets.
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Academic Article
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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic ß cell death and diabetes.
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Academic Article
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Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery.
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Academic Article
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Weight loss therapy improves pancreatic endocrine function in obese older adults.
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Academic Article
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Insulin signaling in alpha cells modulates glucagon secretion in vivo.
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Academic Article
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Glyburide enhances the responsiveness of the beta-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus.
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Academic Article
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
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Academic Article
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Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.
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Academic Article
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In vivo pulsatility of pancreatic islet peptides.
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Academic Article
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Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.
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Academic Article
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Quantitative study of insulin secretion and clearance in normal and obese subjects.
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Academic Article
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Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
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Academic Article
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The limitations to and valid use of C-peptide as a marker of the secretion of insulin.
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Academic Article
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Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
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Academic Article
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Insulin Wakayama: familial mutant insulin syndrome in Japan.
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Academic Article
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Insulin and glucagon breakthrough of somatostatin suppression: importance of portal vein hormone measurements.
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Academic Article
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Responses of somatostatin components to oral glucose in human plasma.
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Academic Article
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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.
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Academic Article
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Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
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Academic Article
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Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
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Academic Article
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Quantitative evaluation of the effect of low-intensity exercise on insulin secretion in man.
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Academic Article
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Pdx1 and other factors that regulate pancreatic beta-cell survival.
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Academic Article
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Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes.
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Academic Article
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Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets.
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Academic Article
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Reevaluation of urine C-peptide as measure of insulin secretion.
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Academic Article
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Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
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Academic Article
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Mutant insulin syndrome: identification of two families with [LeuA3]insulin and determination of its biological activity.
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Academic Article
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Effect of glyburide on beta cell responsiveness to glucose in non-insulin-dependent diabetes mellitus.
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Academic Article
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The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes.
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Academic Article
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The effects of biosynthetic human proinsulin on carbohydrate metabolism.
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Academic Article
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Peripheral insulin parallels changes in insulin secretion more closely than C-peptide after bolus intravenous glucose administration.
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Academic Article
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Defects in insulin secretion and action in women with a history of gestational diabetes.
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Academic Article
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A new method for comparing portal and peripheral venous insulin delivery in humans: tolbutamide versus insulin infusion.
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Academic Article
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The measurement and validation of the nonsteady-state rates of C-peptide appearance in the dog.
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Academic Article
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A familial glucagonoma syndrome: genetic, clinical and biochemical features.
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Academic Article
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Insulin secretion and clearance. Comparison after oral and intravenous glucose.
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Academic Article
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Calculation of the systemic delivery rate of insulin in normal man.
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Academic Article
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Variable deterioration in cortical function during insulin-induced hypoglycemia.
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Academic Article
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Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism.
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Academic Article
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Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
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Academic Article
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Pancreatic hormone profiles and metabolism posthepatectomy in the dog. Evidence for a hepatotrophic role of insulin, glucagon, and pancreatic polypeptide.
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Academic Article
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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
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Academic Article
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Surface receptors for pancreatic hormones in dog and rat hepatocytes: qualitative and quantitative differences in hormone-target cell interactions.
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Academic Article
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Alterations in the patterns of insulin secretion before and after diagnosis of IDDM.
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Academic Article
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C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.
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Academic Article
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Calculated pattern of intraportal insulin appearance without independent assessment of C-peptide kinetics.
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Academic Article
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Lack of effect of high-dose biosynthetic human C-peptide on pancreatic hormone release in normal subjects.
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Academic Article
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Insulin secretion and clearance during low-dose graded glucose infusion.
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Academic Article
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Oscillations in insulin secretion during constant glucose infusion in normal man: relationship to changes in plasma glucose.
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Academic Article
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Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function.
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Academic Article
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Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat.
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Academic Article
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Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
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Academic Article
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Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.
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Academic Article
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Lack of glucagon response to hypoglycemia in type I diabetics after long-term optimal therapy with a continuous subcutaneous insulin infusion pump.
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Academic Article
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Hepatic metabolism of glucagon in the dog: contribution of the liver to overall metabolic disposal of glucagon.
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Academic Article
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Insulin secretion in insulin-resistant women with a history of gestational diabetes.
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Academic Article
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Maturity-onset diabetes of the young.
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Academic Article
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Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
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Academic Article
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Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.
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Academic Article
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Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.
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Academic Article
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Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion.
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Academic Article
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Insulin secretory profiles and C-peptide clearance kinetics at 6 months and 2 years after kidney-pancreas transplantation.
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Academic Article
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Long-term follow-up of canine segmental pancreatic autografts.
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Academic Article
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The past 200 years in diabetes.
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Academic Article
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Natural history of intrahepatic canine islet cell autografts.
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Academic Article
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Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans.
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Academic Article
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The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes.
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Academic Article
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Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.
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Academic Article
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Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.
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Academic Article
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Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome.
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Academic Article
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Glucose counterregulation in patients after pancreatectomy. Comparison with other clinical forms of diabetes.
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Academic Article
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A novel point mutation in the insulin gene giving rise to hyperproinsulinemia.
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Academic Article
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Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research.
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Academic Article
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Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM.
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Academic Article
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Reduced levels of messenger ribonucleic acid for calcium channel, glucose transporter-2, and glucokinase are associated with alterations in insulin secretion in fasted rats.
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Academic Article
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Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat.
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Academic Article
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Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus.
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Academic Article
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Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
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Academic Article
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Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning.
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Academic Article
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Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
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Academic Article
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Diagnosis of acromegaly in a patient with type 1 diabetes mellitus.
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Academic Article
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Organ alchemy: producing insulin in the liver.
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Academic Article
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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
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Academic Article
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Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.
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Academic Article
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International trial of the Edmonton protocol for islet transplantation.
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Academic Article
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Hypoglycemic thresholds for cognitive dysfunction in humans.
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Academic Article
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Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic ß-cells.
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Academic Article
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Effects of aging on insulin secretion.
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Academic Article
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Ginseng and ginsenoside Re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.
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Academic Article
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Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas.
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Academic Article
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Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans.
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Academic Article
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Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
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Academic Article
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Current approaches to measurement of insulin secretion.
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Academic Article
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C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations.
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Academic Article
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Glucose ingestion in dogs alters the hepatic extraction of insulin. In vivo evidence for a relationship between biologic action and extraction of insulin.
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Academic Article
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24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
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Academic Article
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Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
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Academic Article
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Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus.
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Academic Article
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Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus.
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Academic Article
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Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
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Academic Article
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Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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BH3-only molecule Bim mediates ß-cell death in IRS2 deficiency.
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Academic Article
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Pancreatic ß-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.
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Academic Article
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Phase-locking regions in a forced model of slow insulin and glucose oscillations.
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