| Item Type | Name |
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Concept
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Mice, Inbred Strains
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Concept
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Mice, Transgenic
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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Inbred DBA
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Concept
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Mice, Knockout
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Concept
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Mice
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Concept
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Mice, Mutant Strains
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Concept
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Mice, SCID
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Concept
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Mice, Inbred NOD
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Academic Article
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Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells.
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Academic Article
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An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.
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Academic Article
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Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes.
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Academic Article
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Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
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Academic Article
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Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
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Academic Article
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Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus.
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Academic Article
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Episodic ß-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice.
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Academic Article
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Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging.
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Academic Article
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Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.
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Academic Article
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The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.
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Academic Article
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A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo.
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Academic Article
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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
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Academic Article
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Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.
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Academic Article
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IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
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Academic Article
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Interleukin-6 Reduces ß-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response.
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Academic Article
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eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes.
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Academic Article
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1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.
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Academic Article
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Detection of islet ß-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.
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Academic Article
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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.
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Academic Article
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In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo.
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Academic Article
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Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.
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Academic Article
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AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
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Academic Article
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Mouse and human islets survive and function after coating by biosilicification.
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Academic Article
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Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced ß-cell death.
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Academic Article
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Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.
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Academic Article
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Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.
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Academic Article
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Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet ß cells.
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Academic Article
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Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
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Academic Article
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Expression and function of Set7/9 in pancreatic islets.
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Academic Article
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SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet ß Cell.
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Academic Article
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The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter.
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Academic Article
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A system for detecting high impact-low frequency mutations in primary tumors and metastases.
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Academic Article
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Development of insulin-producing cells from primitive biologic precursors.
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Academic Article
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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
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Academic Article
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Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.
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Academic Article
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Research resource: nuclear hormone receptor expression in the endocrine pancreas.
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Academic Article
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12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.
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Academic Article
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Translational control of inducible nitric oxide synthase by p38 MAPK in islet ß-cells.
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Academic Article
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Inhibition of 12/15-Lipoxygenase Protects Against ß-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.
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Academic Article
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Targeting regulatory T cells in the treatment of type 1 diabetes mellitus.
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Academic Article
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Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.
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Academic Article
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Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
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Academic Article
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Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 diabetes.
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Academic Article
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Regulation of the pancreatic pro-endocrine gene neurogenin3.
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Academic Article
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Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease.
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Academic Article
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Peroxisome Proliferator-activated Receptor-? Activation Augments the ß-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and ß Cell Death in Non-obese Diabetic Mice.
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Academic Article
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Transcriptional activity of the islet ß cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
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Academic Article
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Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.
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Academic Article
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Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
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Academic Article
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Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.
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Academic Article
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Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.
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Academic Article
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?40 Isoform of p53 controls ß-cell proliferation and glucose homeostasis in mice.
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Academic Article
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Maintenance of Pdx1 mRNA translation in islet ß-cells during the unfolded protein response.
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Academic Article
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Inducible pluripotent stem cells: not quite ready for prime time?
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Academic Article
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The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.
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Academic Article
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An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.
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Academic Article
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Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
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Academic Article
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Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway.
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Academic Article
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Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.
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Academic Article
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Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.
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Academic Article
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Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.
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Academic Article
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Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
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Academic Article
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Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.
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Academic Article
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Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.
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Academic Article
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Islet ß-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.
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Academic Article
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Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.
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Academic Article
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Loss of mTORC1 signalling impairs ß-cell homeostasis and insulin processing.
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Academic Article
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Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
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Academic Article
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Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
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Academic Article
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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.
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Academic Article
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Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
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Academic Article
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Oligomeric collagen as an encapsulation material for islet/ß-cell replacement: effect of islet source, dose, implant site, and administration format.
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Academic Article
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Hypusination Orchestrates the Antimicrobial Response of Macrophages.
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Academic Article
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Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice.
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Academic Article
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Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention.
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