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Cohn, Susan L.
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overview Our long-term research interest is to improve the outcome for children with neuroblastoma. We are conducting laboratory-based research focused on understanding the cellular pathways that drive clinically aggressive neuroblastoma growth in order to identify actionable mutations that can be targeted and tested in clinical trials. We have an active collaboration with Drs. Chuan He and Lucy Godley investigating the epigenetic landscape of neuroblastoma. We are also collaborating with Dr. Sam Volchenboum and Dr. Robert Grossman to build an International Neuroblastoma Risk Group (INRG) Data Commons that contain phenotype data on a large cohort of neuroblastoma patients diagnosed around the world. The database was built with technology that allows connections with other databases that contain clinical and genomic information on patients with neuroblastoma diagnosed around the world. These data are available to investigators for data mining studies. Currently, clinical information on >20,000 patients with neuroblastoma are included in the INRG Data Commons. More than 20 research projects have been performed, and many of which would not have been possible with smaller patient cohorts.
phone +1 (773) 702-2571
One or more keywords matched the following items that are connected to Cohn, Susan L.
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Concept Adrenalectomy
Concept Age Factors
Concept Algorithms
Concept Administration, Oral
Concept Antineoplastic Agents
Concept Antimetabolites, Antineoplastic
Concept Chromosomes, Human, Pair 11
Concept Antibodies, Monoclonal
Concept Body Height
Concept Birth Weight
Concept Biopsy
Concept Carcinoma, Non-Small-Cell Lung
Concept Chromosomes, Human, Pair 1
Concept Chicago
Concept Glutamate-Cysteine Ligase
Concept Contraceptive Agents, Female
Concept Dacarbazine
Concept DNA, Mitochondrial
Concept Interleukin-2
Concept Decision Support Techniques
Concept DNA Repair
Concept Cyclophosphamide
Concept Chromosomes, Human, Pair 17
Concept Etoposide
Concept Ferritins
Concept Microtubule-Associated Proteins
Concept Karyotyping
Concept Liver Neoplasms
Concept Hydroxamic Acids
Concept Mitotic Index
Concept Mitosis
Concept Immunohistochemistry
Concept Morbidity
Concept Cholesterol, HDL
Concept Orbital Neoplasms
Concept Prednisone
Concept Gangliosides
Concept Recurrence
Concept Risk Factors
Concept Cohort Studies
Concept Japan
Concept Incidence
Concept Cluster Analysis
Concept Tretinoin
Concept Wernicke Encephalopathy
Concept Iodine Radioisotopes
Concept Isotretinoin
Concept Hematopoietic Stem Cell Transplantation
Concept Mycobacterium avium-intracellulare Infection
Concept Randomized Controlled Trials as Topic
Concept Radiopharmaceuticals
Concept Myeloablative Agonists
Concept Hepatitis A Vaccines
Concept Central Nervous System Neoplasms
Concept Leukemia, Myeloid, Acute
Concept Chi-Square Distribution
Concept Stem Cell Transplantation
Concept Proto-Oncogene Proteins c-myc
Concept Case-Control Studies
Concept Age Distribution
Concept Ecosystem
Concept Paraffin Embedding
Concept Tissue Fixation
Concept Cell Proliferation
Concept Disease Progression
Concept Immunomagnetic Separation
Concept Fluorodeoxyglucose F18
Concept Antineoplastic Agents, Alkylating
Concept Limbic Encephalitis
Concept Angiogenesis Inhibitors
Concept Opsoclonus-Myoclonus Syndrome
Concept Lymphocyte Count
Concept Bone Marrow Neoplasms
Concept In Situ Hybridization, Fluorescence
Concept Fatal Outcome
Concept Topoisomerase I Inhibitors
Concept Hepatitis A Antibodies
Concept Peripheral Blood Stem Cell Transplantation
Concept B7-H1 Antigen
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Palmitic Acid
Concept Response Elements
Concept Parents
Concept Lactic Acid
Concept Loss of Heterozygosity
Concept Gravidity
Concept Interdisciplinary Communication
Concept Health Status Disparities
Concept Tetanus Toxoid
Concept Antibodies, Monoclonal, Humanized
Concept Human Umbilical Vein Endothelial Cells
Concept Suspensions
Concept Blotting, Western
Concept HIV Infections
Concept Hypoxia-Inducible Factor 1
Concept Genes, myc
Concept DNA Copy Number Variations
Concept Drug Monitoring
Concept Cell Hypoxia
Concept Survival Rate
Concept Clinical Trials, Phase III as Topic
Concept DNA Methylation
Concept Gene Silencing
Concept Xenograft Model Antitumor Assays
Concept CD4 Lymphocyte Count
Concept Pregnancy Rate
Concept Microsatellite Repeats
Concept Anti-HIV Agents
Concept Tubulin Modulators
Concept Transcriptome
Concept Receptors, KIR2DL1
Concept Genome-Wide Association Study
Concept Cytochromes c
Concept Cell Line, Tumor
Concept Comparative Genomic Hybridization
Concept Intention to Treat Analysis
Concept Epigenomics
Concept Brain Neoplasms
Concept Capsules
Concept Cell Nucleolus
Concept Clinical Trials as Topic
Concept Disease Models, Animal
Concept Doxorubicin
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Retrospective Studies
Concept Sex Education
Concept Translocation, Genetic
Concept HIV-1
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Cost of Illness
Concept Fenretinide
Concept Age of Onset
Concept Computational Biology
Concept Viral Load
Concept Genetic Predisposition to Disease
Concept Genomics
Academic Article The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth.
Academic Article Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children's Oncology Group study.
Academic Article Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.
Academic Article Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth.
Academic Article Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.
Academic Article Opsoclonus-myoclonus and anti-Hu positive limbic encephalitis in a patient with neuroblastoma.
Academic Article Locoregional MYCN-amplified neuroblastoma.
Academic Article Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.
Academic Article Changes over three decades in outcome and the prognostic influence of age-at-diagnosis in young patients with neuroblastoma: a report from the International Neuroblastoma Risk Group Project.
Academic Article Outcome after reduced chemotherapy for intermediate-risk neuroblastoma.
Academic Article Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study.
Academic Article Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.
Academic Article Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project.
Academic Article Prognostic value of the stage 4S metastatic pattern and tumor biology in patients with metastatic neuroblastoma diagnosed between birth and 18 months of age.
Academic Article Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children's Oncology Group study P9641.
Academic Article A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children's Oncology Group study.
Academic Article Progression-free survival of two cases of high-risk neuroblastoma with refractory/relapsed disease following surgery alone.
Academic Article Children's Oncology Group's 2013 blueprint for research: neuroblastoma.
Academic Article Semiquantitative mIBG scoring as a prognostic indicator in patients with stage 4 neuroblastoma: a report from the Children's oncology group.
Academic Article Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group.
Academic Article Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study.
Academic Article Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project.
Academic Article ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.
Academic Article Pilot induction regimen incorporating pharmacokinetically guided topotecan for treatment of newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study.
Academic Article Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project.
Academic Article Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression.
Academic Article Trans-population analysis of genetic mechanisms of ethnic disparities in neuroblastoma survival.
Academic Article Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: A study from the International Neuroblastoma Risk Group Database.
Academic Article Development of an open-source, flexible framework for complex inter-institutional disparate data sharing and collaboration.
Academic Article TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Academic Article Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project.
Academic Article Significance of clinical and biologic features in Stage 3 neuroblastoma: a report from the International Neuroblastoma Risk Group project.
Academic Article Advances in the treatment of neuroblastoma.
Academic Article Second malignancies in patients with neuroblastoma: the effects of risk-based therapy.
Academic Article Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group.
Academic Article Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group.
Academic Article New aspects of neuroblastoma treatment: ASPHO 2011 symposium review.
Academic Article Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial.
Academic Article Neuroblastoma in older children, adolescents and young adults: a report from the International Neuroblastoma Risk Group project.
Academic Article Time to disease progression in children with relapsed or refractory neuroblastoma treated with ABT-751: a report from the Children's Oncology Group (ANBL0621).
Academic Article Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter™ system.
Academic Article Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
Academic Article Treatment of two cases with refractory, metastatic intermediate-risk neuroblastoma with isotretenoin alone or observation.
Academic Article Secondary malignant neoplasms after high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma.
Academic Article Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.
Academic Article Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
Academic Article Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma.
Academic Article A Selfless Act.
Academic Article Genetic discoveries and treatment advances in neuroblastoma.
Academic Article Comparative pharmacokinetics, safety, and tolerability of two sources of ch14.18 in pediatric patients with high-risk neuroblastoma following myeloablative therapy.
Academic Article Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence.
Academic Article A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma.
Academic Article Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database.
Academic Article Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.
Academic Article Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse.
Academic Article Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project.
Academic Article The Role of Nursing Professionals in the Management of Patients With High-Risk Neuroblastoma Receiving Dinutuximab Therapy.
Academic Article Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids.
Academic Article Rebound thymic hyperplasia following high dose chemotherapy and stem cell transplant in three neuroblastoma patients.
Academic Article Data Commons to Support Pediatric Cancer Research.
Academic Article Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Academic Article Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study.
Academic Article Evaluation of Genetic Predisposition for MYCN-Amplified Neuroblastoma.
Academic Article Emerging and investigational therapies for neuroblastoma.
Academic Article Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): a randomised, open-label, phase 3 trial.
Academic Article Immune Reconstitution Following Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma at the Time of Immunotherapy.
Academic Article Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma.
Academic Article Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.
Academic Article Composite tumor with pheochromocytoma and immature neuroblastoma: report of two cases with cytogenetic analysis and discussion of current terminology.
Academic Article Neuroblastoma Patients' KIR and KIR-Ligand Genotypes Influence Clinical Outcome for Dinutuximab-based Immunotherapy: A Report from the Children's Oncology Group.
Academic Article The challenge of defining "ultra-high-risk" neuroblastoma.
Academic Article Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma.
Academic Article MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group.
Grant VARIATIONS BETWEEN RURAL AND URBAN AIDS CARE
Grant Mechanism of SPARC peptide FSEC inhibition of angiogenesis in neuroblastoma
Academic Article A pilot study of tandem high-dose chemotherapy with stem cell rescue as consolidation for high-risk neuroblastoma: Children's Oncology Group study ANBL00P1.
Academic Article Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project.
Academic Article Statistical Framework in Support of a Revised Children's Oncology Group Neuroblastoma Risk Classification System.
Academic Article Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma.
Academic Article Role of the extent of prophylactic regional lymph node radiotherapy on survival in high-risk neuroblastoma: A report from the COG A3973 study.
Academic Article 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype.
Academic Article Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Academic Article Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.
Academic Article Unrealistic parental expectations for cure in poor-prognosis childhood cancer.
Academic Article Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Academic Article 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma: An INRG Project.
Academic Article Racial and Ethnic Differences in Communication and Care for Children With Advanced Cancer.
Academic Article The prognostic strength of serum LDH and serum ferritin in children with neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project.
Academic Article Paraneoplastic opsoclonus myoclonus syndrome associated with inflammatory myofibroblastic tumor in a pediatric patient.
Academic Article Association between end-induction response according to the revised International Neuroblastoma Response Criteria (INRC) and outcome in high-risk neuroblastoma patients.
Academic Article Reply to K. Beiske et al.
Academic Article Tailoring Therapy for Children With Neuroblastoma on the Basis of Risk Group Classification: Past, Present, and Future.
Academic Article A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high-risk neuroblastoma: An International Neuroblastoma Risk Group project.
Academic Article Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032.
Academic Article Stage 4S Neuroblastoma: Molecular, Histologic, and Immunohistochemical Characteristics and Presence of 2 Distinct Patterns of MYCN Protein Overexpression-A Report From the Children's Oncology Group.
Academic Article Association Between Participation in Clinical Trials and Overall Survival Among Children With Intermediate- or High-risk Neuroblastoma.
Academic Article Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma.
Academic Article Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report From NANT Consortium.
Academic Article Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group.
Academic Article Pediatric Cancer Data Commons: Federating and Democratizing Data for Childhood Cancer Research.
Academic Article Beyond one pill, once daily: current challenges of antiretroviral therapy management in the United States.
Academic Article HIV stigma and viral load among African-American women receiving treatment for HIV.
Academic Article Women in HIV trials: improving adherence and outcomes.
Academic Article Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group.
Academic Article Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy.
Academic Article Two-drug HIV regimens: more data still needed.
Academic Article Repeat pregnancies among HIV-infected women enrolled in clinical trial PACTG1022.
Academic Article Long-term follow-up of HIV-infected individuals who have significant increases in CD4+ cell counts during antiretroviral therapy.
Academic Article Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletion.
Academic Article Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy.
Academic Article Irinotecan and temozolomide for treatment of neuroblastoma in a patient with renal failure on hemodialysis.
Academic Article Predicting Response to Chemotherapy in Patients With Newly Diagnosed High-Risk Neuroblastoma: A Report From the International Neuroblastoma Risk Group.
Academic Article Rethinking high-risk neuroblastoma treatment.
Academic Article Efficacy of post-induction therapy for high-risk neuroblastoma patients with end-induction residual disease.
Academic Article Outcomes Following GD2-Directed Postconsolidation Therapy for Neuroblastoma After Cessation of Random Assignment on ANBL0032: A Report From the Children's Oncology Group.
Academic Article MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.
Academic Article A Community Call to Action to Prioritize Inclusion and Enrollment of Women in HIV Cure-related Research.
Academic Article The Experience of Children With Neuroblastoma and Their Parents During Single-Room Isolation for 131I-Metaiodobenzylguanidine Therapy: A Qualitative Descriptive Study.
Academic Article Long-Term Morbidity and Mortality Among Survivors of Neuroblastoma Diagnosed During Infancy: A Report From the Childhood Cancer Survivor Study.
Academic Article Multimodality treatment for recurrent neuroblastoma in the central nervous system.
Concept Rituximab
Concept Filgrastim
Concept N-Myc Proto-Oncogene Protein
Concept Antineoplastic Agents, Immunological
Academic Article Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12- to 18-Month Change in Age Cutoff in Children's Oncology Group Risk Stratification.
Academic Article T-cell inflammation is prognostic of survival in patients with high-risk neuroblastoma enriched for an adrenergic signature.
Academic Article Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Academic Article Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Academic Article In Memoriam: Sharon B. Murphy, MD (1943-2023).
Academic Article Factors influencing parents' choice of palliative treatment goals for children with relapsed or refractory neuroblastoma: A multi-site longitudinal survey study.
Academic Article Persistence of Racial and Ethnic Disparities in Risk and Survival for Patients with Neuroblastoma over Two Decades.
Academic Article Impact of Risk-Based therapy on late morbidity and mortality in neuroblastoma survivors: a report from the childhood cancer survivor study.
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