Proto-Oncogene Proteins c-myc
"Proto-Oncogene Proteins c-myc" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic helix-loop-helix transcription factors encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.
| Descriptor ID |
D016271
|
| MeSH Number(s) |
D12.776.260.103.813 D12.776.624.664.700.189 D12.776.660.765 D12.776.930.125.813
|
| Concept/Terms |
Proto-Oncogene Proteins c-myc- Proto-Oncogene Proteins c-myc
- Proto Oncogene Proteins c myc
- myc Proto-Oncogene Product p62
- myc Proto Oncogene Product p62
- Proto-Oncogene Proteins myc
- Proteins myc, Proto-Oncogene
- Proto Oncogene Proteins myc
- myc, Proto-Oncogene Proteins
- p62 c-myc
- p62 c myc
- p62(c-myc)
- Proto-Oncogene Products c-myc
- Proto Oncogene Products c myc
- c-myc Proteins
- c myc Proteins
- myc Proto-Oncogene Proteins
- Proto-Oncogene Proteins, myc
- myc Proto Oncogene Proteins
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-myc".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-myc".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-myc" by people in this website by year, and whether "Proto-Oncogene Proteins c-myc" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 1 | 3 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 4 | 5 |
| 2008 | 0 | 4 | 4 |
| 2009 | 4 | 0 | 4 |
| 2010 | 3 | 4 | 7 |
| 2011 | 1 | 1 | 2 |
| 2012 | 3 | 2 | 5 |
| 2013 | 3 | 4 | 7 |
| 2014 | 2 | 4 | 6 |
| 2015 | 4 | 5 | 9 |
| 2016 | 8 | 3 | 11 |
| 2017 | 4 | 4 | 8 |
| 2018 | 4 | 3 | 7 |
| 2019 | 4 | 4 | 8 |
| 2020 | 2 | 3 | 5 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 3 | 3 |
| 2024 | 1 | 3 | 4 |
| 2025 | 3 | 0 | 3 |
| 2026 | 3 | 1 | 4 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-myc" by people in Profiles.
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The Genomic Landscape of MYC-, MYCL-, and MYCN-Amplified Solid Tumors. Clin Cancer Res. 2026 Sep 15; 32(18):4124-4135.
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Chromatin rewiring of ß-globin and MYC enhancers by TGF-ß1 drives defective erythropoiesis. Nat Commun. 2026 May 13; 17(1).
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l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression. J Clin Invest. 2026 May 01; 136(9).
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FBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome. J Clin Invest. 2026 Jan 16; 136(2).
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A multicenter phase 1/2 trial of lenalidomide and dose-adjusted EPOCH-R in MYC-associated DLBCL. Blood Adv. 2025 Nov 11; 9(21):5665-5675.
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Structural basis for nucleolin recognition of MYC promoter G-quadruplex. Science. 2025 04 18; 388(6744):eadr1752.
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Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma. Neoplasia. 2025 05; 63:101152.
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Central control of dynamic gene circuits governs T cell rest and activation. Nature. 2025 01; 637(8047):930-939.
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A kinome drug screen identifies multi-TKI synergies and ERBB2 signaling as a therapeutic vulnerability in MYC/TYR subgroup atypical teratoid rhabdoid tumors. Neuro Oncol. 2024 Oct 03; 26(10):1895-1911.
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MGA deletion leads to Richter's transformation by modulating mitochondrial OXPHOS. Sci Transl Med. 2024 07 31; 16(758):eadg7915.