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Bell, Graeme

One or more keywords matched the following properties of Bell, Graeme

Property	Value
keywords	Insulin mutations and diabetes

One or more keywords matched the following items that are connected to Bell, Graeme

Item Type	Name
Concept	Insulin
Concept	Insulin-Like Growth Factor II
Concept	Receptor, Insulin
Concept	Insulin Resistance
Concept	Insulin-Secreting Cells
Concept	Insulin Receptor Substrate Proteins
Concept	Insulin, Regular, Human
Academic Article	Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism.
Academic Article	Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.
Academic Article	Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
Academic Article	Glucokinase mutations, insulin secretion, and diabetes mellitus.
Academic Article	Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
Academic Article	The aggregation of the 5' insulin gene polymorphism in insulin dependent (type I) diabetes mellitus families.
Academic Article	Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
Academic Article	Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
Academic Article	Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
Academic Article	Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
Academic Article	Maturity onset diabetes of the young (MODY).
Academic Article	Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.
Academic Article	Nature or nurture: an insightful illustration from a Chinese family with hepatocyte nuclear factor-1 alpha diabetes (MODY3)
Academic Article	Evidence that insulin is imprinted in the human yolk sac.
Academic Article	Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.
Academic Article	A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.
Academic Article	Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
Academic Article	Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene.
Academic Article	Neonatal diabetes mellitus due to complete glucokinase deficiency.
Academic Article	Calpains play a role in insulin secretion and action.
Academic Article	Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury.
Academic Article	Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome.
Academic Article	Diabetes mellitus and genetically programmed defects in beta-cell function.
Academic Article	Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Academic Article	A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
Academic Article	Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.
Academic Article	Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.
Academic Article	Anti-diabetic effect of ginsenoside Re in ob/ob mice.
Academic Article	Insulin gene mutations as a cause of permanent neonatal diabetes.
Academic Article	Noninvasive monitoring of changes in pancreatic beta-cell mass by bioluminescent imaging in MIP-luc transgenic mice.
Academic Article	Diagnosis and treatment of neonatal diabetes: a United States experience.
Academic Article	Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
Academic Article	Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
Academic Article	Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome.
Academic Article	Update in neonatal diabetes.
Academic Article	Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.
Academic Article	Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
Academic Article	A brief perspective on insulin production.
Academic Article	Neonatal diabetes mellitus: a model for personalized medicine.
Academic Article	Seeing is believing: how the MIP-luc mouse can advance the field of islet transplantation and ß-cell regeneration.
Academic Article	Onset features and subsequent clinical evolution of childhood diabetes over several years.
Academic Article	Calpain-10 gene and protein expression in human skeletal muscle: effect of acute lipid-induced insulin resistance and type 2 diabetes.
Academic Article	TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
Academic Article	An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.
Academic Article	Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes.
Academic Article	Identification of two novel amino acid polymorphisms in beta-cell/liver (GLUT2) glucose transporter in Japanese subjects.
Academic Article	Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
Academic Article	Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.
Academic Article	Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.
Academic Article	Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
Academic Article	Clinical characteristics of subjects with a missense mutation in glucokinase.
Academic Article	Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.
Academic Article	Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects.
Academic Article	Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
Academic Article	Maturity-onset diabetes of the young.
Academic Article	Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
Academic Article	In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
Academic Article	Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.
Academic Article	A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.
Academic Article	Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.
Academic Article	Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations.
Academic Article	Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.
Academic Article	Variation in the calpain-10 gene affects blood glucose levels in the British population.
Academic Article	Organ alchemy: producing insulin in the liver.
Academic Article	Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family.
Academic Article	Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.
Academic Article	5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Academic Article	Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
Academic Article	Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic ß-cells.
Academic Article	Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.
Academic Article	Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
Academic Article	Creation of an inositol 1,4,5-trisphosphate-sensitive Ca2+ store in secretory granules of insulin-producing cells.
Academic Article	Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family.
Academic Article	Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.
Academic Article	Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin.
Academic Article	In vitro scan for enhancers at the TCF7L2 locus.
Academic Article	Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
Academic Article	GSK-3ß function in bone regulates skeletal development, whole-body metabolism, and male life span.
Academic Article	Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.
Academic Article	Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Academic Article	Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism.
Academic Article	Resting beta-cells - A functional reserve?
Academic Article	A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Academic Article	In vivo measurement and biological characterisation of the diabetes-associated mutant insulin p.R46Q (GlnB22-insulin).
Academic Article	A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
Academic Article	In celebration of a century with insulin - Update of insulin gene mutations in diabetes.
Grant	GENES FOR NON-INSULIN-DEPENDENT DIABETES MELLITUS
Grant	MOLECULAR MECHANISMS/BETA CELL DYSFUNCTION IN DIABETES
Grant	GENES RESPONSIBLE IN INSULIN-DEPENDENT DIABETES MELLITUS

Search Criteria

Insulin