| Item Type | Name |
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Concept
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Insulin
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Concept
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Insulin-Like Growth Factor I
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Concept
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Receptor, Insulin
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Concept
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Insulin Resistance
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Concept
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Insulin-Secreting Cells
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Concept
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Insulin, Regular, Human
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Academic Article
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K+ channels: generating excitement in pancreatic beta-cells.
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Academic Article
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Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.
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Academic Article
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Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice.
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Academic Article
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Beta-cell ion channels: keys to endodermal excitability.
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Academic Article
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Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.
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Academic Article
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
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Academic Article
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TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells.
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Academic Article
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beta-Agonists and metabolism.
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Academic Article
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Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?
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Academic Article
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Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
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Academic Article
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Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.
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Academic Article
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Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.
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Academic Article
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Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.
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Academic Article
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Insulin gene mutations as a cause of permanent neonatal diabetes.
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Academic Article
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Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.
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Academic Article
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When BAD is good for beta cells.
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Academic Article
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Diagnosis and treatment of neonatal diabetes: a United States experience.
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Academic Article
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Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
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Academic Article
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Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.
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Academic Article
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A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.
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Academic Article
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Update in neonatal diabetes.
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Academic Article
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Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
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Academic Article
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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
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Academic Article
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A brief perspective on insulin production.
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Academic Article
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TRP channels of the pancreatic beta cell.
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Academic Article
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Functional MR microimaging of pancreatic beta-cell activation.
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Academic Article
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Neonatal diabetes mellitus: a model for personalized medicine.
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Academic Article
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Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
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Academic Article
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Action potentials and insulin secretion: new insights into the role of Kv channels.
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Academic Article
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Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis.
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Academic Article
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Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.
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Academic Article
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Delayed rectifier K+ channel overexpression in transgenic islets and beta-cells associated with impaired glucose responsiveness.
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Academic Article
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The granular chloride channel ClC-3 is permissive for insulin secretion.
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Academic Article
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SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion.
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Academic Article
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Reactive species and early manifestation of insulin resistance in type 2 diabetes.
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Academic Article
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A gene fusion system for generating antibodies against short peptides.
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Academic Article
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Pas de deux or more: the sulfonylurea receptor and K+ channels.
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Academic Article
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Production of specific antibodies against protein A fusion proteins.
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Academic Article
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Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans.
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Academic Article
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Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis.
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Academic Article
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Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells.
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Academic Article
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The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution.
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Academic Article
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In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
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Academic Article
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Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses.
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Academic Article
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Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.
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Academic Article
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Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
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Academic Article
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Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
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Academic Article
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Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches.
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Academic Article
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Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.
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Academic Article
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Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
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Academic Article
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Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect.
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Academic Article
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Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.
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Academic Article
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Glucose-induced ERM protein activation and translocation regulates insulin secretion.
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Academic Article
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Efficient secretion and purification of human insulin-like growth factor I with a gene fusion vector in Staphylococci.
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Academic Article
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ß-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.
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Academic Article
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Intracellular transport of insulin granules is a subordinated random walk.
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Academic Article
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Ion channels and regulation of insulin secretion in human ß-cells: a computational systems analysis.
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Academic Article
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Transgenic zebrafish model of the C43G human insulin gene mutation.
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Academic Article
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Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.
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Academic Article
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Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ß cells.
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Academic Article
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Lean versus obese diabetes mellitus patients in the United States minority population.
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Academic Article
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The role of ß cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
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Academic Article
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Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets.
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Academic Article
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Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells.
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Academic Article
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Role of noninsulin therapies alone or in combination in chromosome 6q24-related transient neonatal diabetes: sulfonylurea improves but does not always normalize insulin secretion.
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Academic Article
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Insulin dosing in pediatric diabetic ketoacidosis: where to start?
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Academic Article
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Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.
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Academic Article
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Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism.
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Academic Article
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Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis.
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Academic Article
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PGC-1 coactivators in ß-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids.
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Academic Article
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TCF1 links GIPR signaling to the control of beta cell function and survival.
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Academic Article
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A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling.
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Academic Article
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Resting beta-cells - A functional reserve?
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Academic Article
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Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes.
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Academic Article
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External Validation of the Newly Developed BETA-2 Scoring System for Pancreatic Islet Graft Function Assessment.
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Academic Article
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Early Intensive Insulin Use May Preserve ß-Cell Function in Neonatal Diabetes Due to Mutations in the Proinsulin Gene.
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Academic Article
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Simultaneous Real-Time Measurement of the ß-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ß-Cell Function.
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Academic Article
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a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
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Academic Article
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Human islets expressing HNF1A variant have defective ß cell transcriptional regulatory networks.
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Academic Article
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Comparative evaluation of simple indices using a single fasting blood sample to estimate beta cell function after islet transplantation.
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Academic Article
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FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
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Academic Article
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Deletion of Protein Kinase D1 in Pancreatic ß-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.
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Academic Article
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Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry.
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Academic Article
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Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2).
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Academic Article
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Harnessing heterogeneity in type 2 diabetes mellitus.
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Academic Article
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Exenatide extended release in patients with type 1 diabetes with and without residual insulin production.
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Grant
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IMAGING BETA CELL FUNCTION WITH BIOSENSORS
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Grant
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K+ Channel Expression in Pancreatic Beta-Cells
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