| Item Type | Name |
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Concept
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Proinsulin
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Academic Article
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
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Academic Article
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Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.
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Academic Article
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
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Academic Article
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
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Academic Article
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Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
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Academic Article
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Insulin-secreting non-islet cells are resistant to autoimmune destruction.
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Academic Article
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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
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Academic Article
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How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.
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Academic Article
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
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Academic Article
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
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Academic Article
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
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Academic Article
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
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Academic Article
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Academic Article
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Proinsulin maturation, misfolding, and proteotoxicity.
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Academic Article
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
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Academic Article
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Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
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Academic Article
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
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Academic Article
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Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
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Academic Article
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[Biogenesis of the insulin secretion granule].
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides.
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Academic Article
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
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Academic Article
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The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
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Academic Article
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
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Academic Article
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Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
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Academic Article
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High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin.
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Academic Article
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets.
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Academic Article
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
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Academic Article
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What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
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Academic Article
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
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Academic Article
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The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.
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Academic Article
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Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
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Academic Article
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets.
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Academic Article
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Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
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Academic Article
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Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin.
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Academic Article
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
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Academic Article
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Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
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Academic Article
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The enzymology of proinsulin conversion.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Grant
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Western Region Islet Study Group
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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