Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.

Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. J Biol Chem. 1992 Nov 15; 267(32):22719-27.

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subject areas

Amino Acid Sequence
Animals
Chromatography, DEAE-Cellulose
Chromatography, High Pressure Liquid
Cytoplasmic Granules
Endopeptidases
Humans
Insulinoma
Kinetics
Molecular Sequence Data
Pancreatic Neoplasms
Peptides
Proinsulin
Protein Precursors
Protein Processing, Post-Translational
Rats
Rats, Inbred Strains
Substrate Specificity

authors with profiles

Christopher J. Rhodes