 Arachidonate 5-Lipoxygenase
"Arachidonate 5-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
| Descriptor ID |
D001094
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| MeSH Number(s) |
D08.811.682.690.416.583.500.055 D12.776.556.579.374.568.500.020
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| Concept/Terms |
Arachidonate 5-Lipoxygenase- Arachidonate 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonate
- Arachidonate 5 Lipoxygenase
- Arachidonic Acid 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 5 Lipoxygenase
- LTA4 Synthase
- Synthase, LTA4
- Leukotriene A4 Synthase
- Synthase, Leukotriene A4
- Leukotriene A4 Synthetase
- Synthetase, Leukotriene A4
- 5-Lipoxygenase
- 5 Lipoxygenase
- Leukotriene A Synthase
- Synthase, Leukotriene A
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Below are MeSH descriptors whose meaning is more general than "Arachidonate 5-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 5-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 5-Lipoxygenase" by people in this website by year, and whether "Arachidonate 5-Lipoxygenase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1994 | 0 | 1 | 1 | | 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 2001 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "Arachidonate 5-Lipoxygenase" by people in Profiles.
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Catanzaro G, Pucci M, Viscomi MT, Lanuti M, Feole M, Angeletti S, Grasselli G, Mandolesi G, Bari M, Centonze D, D'Addario C, Maccarrone M. Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis. J Neuroimmunol. 2016 05 15; 294:32-40.
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Tang F, Sally B, Lesko K, Discepolo V, Abadie V, Ciszewski C, Semrad C, Guandalini S, Kupfer SS, Jabri B. Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease. J Exp Med. 2015 Sep 21; 212(10):1487-95.
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Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH. Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. Sci Signal. 2015 Jan 27; 8(361):ra10.
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Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.
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Edelman MJ, Hodgson L, Wang X, Christenson R, Jewell S, Vokes E, Kratzke R. Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304. J Thorac Oncol. 2011 Nov; 6(11):1902-6.
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Li RC, Haribabu B, Mathis SP, Kim J, Gozal D. Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesis. Am J Respir Crit Care Med. 2011 Jul 01; 184(1):124-31.
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Melstrom LG, Bentrem DJ, Salabat MR, Kennedy TJ, Ding XZ, Strouch M, Rao SM, Witt RC, Ternent CA, Talamonti MS, Bell RH, Adrian TA. Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin Cancer Res. 2008 Oct 15; 14(20):6525-30.
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Meliton AY, Munoz NM, Leff AR. Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion. J Allergy Clin Immunol. 2007 Dec; 120(6):1316-23.
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Tong WG, Ding XZ, Talamonti MS, Bell RH, Adrian TE. LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):949-56.
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Hennig R, Grippo P, Ding XZ, Rao SM, Buchler MW, Friess H, Talamonti MS, Bell RH, Adrian TE. 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Cancer Res. 2005 Jul 15; 65(14):6011-6.
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