 Bicuculline
"Bicuculline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
| Descriptor ID |
D001640
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| MeSH Number(s) |
D03.132.098.077 D03.438.531.085.077
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| Concept/Terms |
Bicuculline- Bicuculline
- 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
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Below are MeSH descriptors whose meaning is more general than "Bicuculline".
Below are MeSH descriptors whose meaning is more specific than "Bicuculline".
This graph shows the total number of publications written about "Bicuculline" by people in this website by year, and whether "Bicuculline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 3 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Bicuculline" by people in Profiles.
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Neugebauer NM, Miyauchi M, Sato T, Tadano J, Akal H, Ardehali H, Meltzer HY. Hippocampal GABAA antagonism reverses the novel object recognition deficit in sub-chronic phencyclidine-treated rats. Behav Brain Res. 2018 04 16; 342:11-18.
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Marcuccilli CJ, Tryba AK, van Drongelen W, Koch H, Viemari JC, Peña-Ortega F, Doren EL, Pytel P, Chevalier M, Mrejeru A, Kohrman MH, Lasky RE, Lew SM, Frim DM, Ramirez JM. Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology. J Clin Neurophysiol. 2010 Dec; 27(6):387-97.
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Foo H, Crabtree K, Mason P. The modulatory effects of rostral ventromedial medulla on air-puff evoked microarousals in rats. Behav Brain Res. 2010 Dec 20; 215(1):156-9.
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Ben-Mabrouk F, Tryba AK. Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci. 2010 Apr; 31(7):1219-32.
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Tryba AK, Peña F, Lieske SP, Viemari JC, Thoby-Brisson M, Ramirez JM. Differential modulation of neural network and pacemaker activity underlying eupnea and sigh-breathing activities. J Neurophysiol. 2008 May; 99(5):2114-25.
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Fagen ZM, Mitchum R, Vezina P, McGehee DS. Enhanced nicotinic receptor function and drug abuse vulnerability. J Neurosci. 2007 Aug 15; 27(33):8771-8.
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Xie Z, Herring BE, Fox AP. Excitatory and inhibitory actions of isoflurane in bovine chromaffin cells. J Neurophysiol. 2006 Dec; 96(6):3042-50.
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Haas JS, Nowotny T, Abarbanel HD. Spike-timing-dependent plasticity of inhibitory synapses in the entorhinal cortex. J Neurophysiol. 2006 Dec; 96(6):3305-13.
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Nason MW, Mason P. Modulation of sympathetic and somatomotor function by the ventromedial medulla. J Neurophysiol. 2004 Jul; 92(1):510-22.
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Yuan CS, Mehendale S, Xiao Y, Aung HH, Xie JT, Ang-Lee MK. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg. 2004 Feb; 98(2):353-8, table of contents.
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