"Papaverine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
| Descriptor ID |
D010208
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| MeSH Number(s) |
D03.132.098.666 D03.132.577.750 D03.633.100.531.085.666
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Papaverine".
Below are MeSH descriptors whose meaning is more specific than "Papaverine".
This graph shows the total number of publications written about "Papaverine" by people in this website by year, and whether "Papaverine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Papaverine" by people in Profiles.
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Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses. J Virol. 2020 02 28; 94(6).
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Current approach to the man with acute phase Peyronie's disease--case presentation and discussion. J Sex Med. 2011 Jun; 8(6):1556-8; quiz 1559.
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Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration. J Cardiovasc Pharmacol. 2008 Dec; 52(6):485-93.
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Experience with intraplaque injection of verapamil for Peyronie's disease. J Urol. 2002 Aug; 168(2):621-5; discussion 625-6.
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Measurement of vascular input impedance in infrainguinal vein grafts. Ann Vasc Surg. 1997 Jan; 11(1):35-43.
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Papaverine-phentolamine and prostaglandin E1 versus papaverine-phentolamine alone for intracorporeal injection therapy: a clinical double-blind study. J Urol. 1995 Sep; 154(3):1017-9.
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Chart for preparation of dilutions of alpha-adrenergic agonists for intracavernous use in treatment of priapism. J Urol. 1995 Apr; 153(4):1182-3.
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Evaluation of changes in skeletal muscle blood flow in the dog with contrast ultrasonography. Plast Reconstr Surg. 1995 Jan; 95(1):114-8.
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Objective double-blind evaluation of erectile function with intracorporeal papaverine in combination with phentolamine and/or prostaglandin E1. J Urol. 1992 Oct; 148(4):1181-3.
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Penile duplex sonography in the diagnosis of venogenic impotence. J Vasc Surg. 1991 Jan; 13(1):75-82; discussion 82-3.