 Botulinum Toxins
"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
| Descriptor ID |
D001905
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| MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
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| Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
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Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
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Allaix ME, Patti MG. Toward a Tailored Treatment of Achalasia: An Evidence-Based Approach. J Laparoendosc Adv Surg Tech A. 2016 Apr; 26(4):256-63.
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Allaix ME, Patti MG. Endoscopic dilatation, heller myotomy, and peroral endoscopic myotomy: treatment modalities for achalasia. Surg Clin North Am. 2015 Jun; 95(3):567-78.
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Rao K, Micic D, Natarajan M, Winters S, Kiel MJ, Walk ST, Santhosh K, Mogle JA, Galecki AT, LeBar W, Higgins PD, Young VB, Aronoff DM. Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Clin Infect Dis. 2015 Jul 15; 61(2):233-41.
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Lo KK, Aycock JK. A blinded randomized controlled trial to evaluate the use of botulinum toxin for pain control in breast reconstruction with tissue expanders. Ann Plast Surg. 2015 Mar; 74(3):281-3.
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Shogan AN, Rogers DJ, Hartnick CJ, Kerschner JE. Use of botulinum toxin in pediatric otolaryngology and laryngology. Int J Pediatr Otorhinolaryngol. 2014 Sep; 78(9):1423-5.
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Patti MG, Fisichella PM. Controversies in management of achalasia. J Gastrointest Surg. 2014 Sep; 18(9):1705-9.
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Wilson SC, Soares MA, Reavey PL, Saadeh PB. Trends and drivers of the aesthetic market during a turbulent economy. Plast Reconstr Surg. 2014 Jun; 133(6):783e-789e.
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Lee DH, Jin SP, Cho S, Feneran A, Youn CS, Won CH, Park GH, Kim BW, An J, Chang SE, Lee MW. RimabotulinumtoxinB versus OnabotulinumtoxinA in the treatment of masseter hypertrophy: a 24-week double-blind randomized split-face study. Dermatology. 2013; 226(3):227-32.
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Lee DH, Kang SM, Feneran A, Youn CS, Kim JK, Cho S, Won CH, Chang SE, Lee MW, Choi JH, Moon KC. RimabotulinumtoxinB vs. onabotulinumtoxinA for the treatment of forehead lines: an evaluator-blind, randomized, pilot study. J Eur Acad Dermatol Venereol. 2013 Jan; 27(1):e1-7.
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Allaix ME, Herbella FA, Patti MG. The evolution of the treatment of esophageal achalasia: a look at the last two decades. Updates Surg. 2012 Sep; 64(3):161-5.
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