 Microbial Collagenase
"Microbial Collagenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
| Descriptor ID |
D003012
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| MeSH Number(s) |
D08.811.277.656.300.480.205.500 D08.811.277.656.675.374.205.500
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| Concept/Terms |
Microbial Collagenase- Microbial Collagenase
- Collalysine
- Clostridium histolyticum Collagenase
- Collagenase, Clostridium histolyticum
- Collagenase, Microbial
- Clostridiopeptidase A
- Nucleolysin
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Below are MeSH descriptors whose meaning is more general than "Microbial Collagenase".
Below are MeSH descriptors whose meaning is more specific than "Microbial Collagenase".
This graph shows the total number of publications written about "Microbial Collagenase" by people in this website by year, and whether "Microbial Collagenase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Microbial Collagenase" by people in Profiles.
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Levine LA, Cuzin B, Mark S, Gelbard MK, Jones NA, Liu G, Kaufman GJ, Tursi JP, Ralph DJ. Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study. J Sex Med. 2015 Jan; 12(1):248-58.
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Levine LA, Larsen SM. Surgical correction of persistent Peyronie's disease following collagenase clostridium histolyticum treatment. J Sex Med. 2015 Jan; 12(1):259-64.
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Gelbard M, Hellstrom WJ, McMahon CG, Levine LA, Smith T, Tursi J, Kaufman G, Goldstein I. Baseline characteristics from an ongoing phase 3 study of collagenase clostridium histolyticum in patients with Peyronie's disease. J Sex Med. 2013 Nov; 10(11):2822-31.
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Gelbard M, Lipshultz LI, Tursi J, Smith T, Kaufman G, Levine LA. Phase 2b study of the clinical efficacy and safety of collagenase Clostridium histolyticum in patients with Peyronie disease. J Urol. 2012 Jun; 187(6):2268-74.
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Ferguson MK. Modulation of lymphatic smooth muscle contractile responses by the endothelium. J Surg Res. 1992 Apr; 52(4):359-63.
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Okamura K, Sato Y, Matsuda T, Hamanaka R, Ono M, Kohno K, Kuwano M. Endogenous basic fibroblast growth factor-dependent induction of collagenase and interleukin-6 in tumor necrosis factor-treated human microvascular endothelial cells. J Biol Chem. 1991 Oct 15; 266(29):19162-5.
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Bassiouny HS, Davis H, Massawa N, Gewertz BL, Glagov S, Zarins CK. Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic plaques. J Vasc Surg. 1989 Feb; 9(2):202-12.
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Waxler B, Corey J, Wezeman FH. Collagenase inhibitory activity in human breast milk. Biochem Med. 1985 Jun; 33(3):279-83.
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