Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
|
| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
|
| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 2 | 3 |
| 1997 | 4 | 4 | 8 |
| 1998 | 5 | 1 | 6 |
| 1999 | 3 | 2 | 5 |
| 2000 | 4 | 2 | 6 |
| 2001 | 6 | 7 | 13 |
| 2002 | 3 | 2 | 5 |
| 2003 | 5 | 6 | 11 |
| 2004 | 9 | 4 | 13 |
| 2005 | 8 | 11 | 19 |
| 2006 | 6 | 2 | 8 |
| 2007 | 7 | 5 | 12 |
| 2008 | 5 | 6 | 11 |
| 2009 | 8 | 5 | 13 |
| 2010 | 5 | 3 | 8 |
| 2011 | 10 | 5 | 15 |
| 2012 | 10 | 3 | 13 |
| 2013 | 4 | 8 | 12 |
| 2014 | 5 | 4 | 9 |
| 2015 | 3 | 9 | 12 |
| 2016 | 10 | 3 | 13 |
| 2017 | 6 | 5 | 11 |
| 2018 | 3 | 4 | 7 |
| 2019 | 2 | 7 | 9 |
| 2020 | 4 | 2 | 6 |
| 2021 | 0 | 6 | 6 |
| 2022 | 2 | 4 | 6 |
| 2023 | 5 | 5 | 10 |
| 2024 | 3 | 2 | 5 |
| 2025 | 4 | 3 | 7 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Controlled release of rhBMP-2 from nanoparticle-loaded biomimetic graft promotes bone regeneration in a rat spinal fusion model. Biomater Adv. 2026 Nov; 188:214989.
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Endoglin as a BMP9 co-receptor in vascular endothelial cells: prodomain displacement and TGFBRII recruitment. Nat Commun. 2025 Dec 31; 17(1):825.
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Epidermal resident memory T cell fitness requires antigen encounter in the skin. Elife. 2025 Dec 30; 14.
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Bridging EGFR/TGF-ß Signaling to Bypass Resistance to Immune Checkpoint Blockade. Clin Cancer Res. 2025 Nov 14; 31(22):4617-4619.
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Mitochondrial one-carbon metabolism is required for TGF-ß-induced glycine synthesis and fibrotic responses. Nat Commun. 2025 Oct 20; 16(1):9250.
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Serum Proteomic Profile Based on the TGF-ß Pathway Stratifies Risk of Hepatocellular Carcinoma. Liver Int. 2025 10; 45(10):e70325.
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Arginine promotes the activation of human lung fibroblasts independent of its metabolism. Biochem J. 2025 06 17; 482(12).
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mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-ß and in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2025 02 01; 328(2):L215-L228.
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Ga12 and Ga13 proteins are required for transforming growth factor-ß-induced myofibroblast differentiation. Biochem J. 2024 12 18; 481(24):1937-1948.
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Exploring the potential of TGFß as a diagnostic marker and therapeutic target against cancer. Biochem Pharmacol. 2025 01; 231:116646.